BAIT
HAVCR1
HAVCR, HAVCR-1, KIM-1, KIM1, TIM, TIM-1, TIM1, TIMD-1, TIMD1
hepatitis A virus cellular receptor 1
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
PREY
SNX6
MSTP010, TFAF2
sorting nexin 6
GO Process (8)
GO Function (4)
GO Component (6)
Gene Ontology Biological Process
- endocytosis [IBA]
- intracellular protein transport [IMP, NAS]
- negative regulation of epidermal growth factor-activated receptor activity [NAS]
- negative regulation of transcription, DNA-templated [IDA]
- negative regulation of transforming growth factor beta receptor signaling pathway [IDA]
- regulation of histamine secretion by mast cell [IMP]
- retrograde transport, endosome to Golgi [IMP]
- vesicle organization [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
TIM-1Â Ubiquitination Mediates Dengue Virus Entry.
Dengue virus (DENV) is a major human pathogen causing millions of infections yearly. Despite intensive investigations, a DENV receptor that directly participates in virus internalization has not yet been characterized. Here, we report that the phosphatidylserine receptor TIM-1 is an authentic DENV entry receptor that plays an active role in virus endocytosis. Genetic ablation of TIM-1 strongly impaired DENV infection. ... [more]
Cell Rep May. 08, 2018; 23(6);1779-1793 [Pubmed: 29742433]
Throughput
- High Throughput
Curated By
- BioGRID