BAIT
CALCOCO2
NDP52
calcium binding and coiled-coil domain 2
GO Process (2)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
SPTBN1
ELF, HEL102, SPTB2, betaSpII
spectrin, beta, non-erythrocytic 1
GO Process (6)
GO Function (4)
GO Component (6)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
NDP52 interacts with mitochondrial RNA poly(A) polymerase to promote mitophagy.
Parkin-mediated mitophagy is a quality control pathway that selectively removes damaged mitochondria via the autophagic machinery. Autophagic receptors, which interact with ubiquitin and Atg8 family proteins, contribute to the recognition of damaged mitochondria by autophagosomes. NDP52, an autophagy receptor, is required for autophagic engulfment of damaged mitochondria during mitochondrial uncoupler treatment. The N-terminal SKICH domain and C-terminal zinc finger motif ... [more]
EMBO Rep. Oct. 11, 2018; (); [Pubmed: 30309841]
Throughput
- High Throughput
Curated By
- BioGRID