BAIT
HIF1A
AA959795, HIF1alpha, MOP1, bHLHe78
hypoxia inducible factor 1, alpha subunit
GO Process (75)
GO Function (18)
GO Component (8)
Gene Ontology Biological Process
- B-1 B cell homeostasis [IMP]
- angiogenesis [IMP]
- axon transport of mitochondrion [ISO]
- blood vessel development [IMP]
- blood vessel morphogenesis [IMP]
- cardiac ventricle morphogenesis [IMP]
- cartilage development [IMP]
- cell differentiation [IGI, IMP]
- cellular iron ion homeostasis [IMP]
- cellular response to hypoxia [IGI, ISO]
- cerebral cortex development [IMP]
- collagen metabolic process [IMP]
- connective tissue replacement involved in inflammatory response wound healing [IMP]
- digestive tract morphogenesis [IMP]
- dopaminergic neuron differentiation [IGI, IMP]
- elastin metabolic process [IMP]
- embryonic hemopoiesis [IMP]
- embryonic placenta development [IGI, IMP]
- epithelial cell differentiation involved in mammary gland alveolus development [IMP]
- epithelial to mesenchymal transition [IMP]
- glucose homeostasis [IMP]
- heart looping [IMP]
- hemoglobin biosynthetic process [IMP]
- hypoxia-inducible factor-1alpha signaling pathway [IDA]
- intestinal epithelial cell maturation [IMP]
- lactate metabolic process [IMP]
- lactation [IMP]
- muscle cell cellular homeostasis [IMP]
- negative regulation of TOR signaling [IMP]
- negative regulation of apoptotic process [IMP, ISO]
- negative regulation of bone mineralization [IMP]
- negative regulation of growth [IMP]
- negative regulation of mesenchymal cell apoptotic process [IMP]
- negative regulation of neuron apoptotic process [IMP]
- negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [ISO]
- negative regulation of thymocyte apoptotic process [IMP]
- negative regulation of transcription elongation from RNA polymerase II promoter [ISO]
- negative regulation of vasoconstriction [ISO]
- neural crest cell migration [IMP]
- neural fold elevation formation [IMP]
- outflow tract morphogenesis [IMP]
- oxygen homeostasis [IMP, ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of epithelial cell migration [IMP]
- positive regulation of erythrocyte differentiation [IMP]
- positive regulation of gene expression [ISO]
- positive regulation of hormone biosynthetic process [ISO]
- positive regulation of insulin secretion involved in cellular response to glucose stimulus [IMP]
- positive regulation of neuroblast proliferation [IGI]
- positive regulation of receptor biosynthetic process [ISO]
- positive regulation of smooth muscle cell proliferation [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, IMP, ISO]
- positive regulation of transcription from RNA polymerase II promoter in response to hypoxia [ISO]
- positive regulation of transcription, DNA-templated [ISO]
- positive regulation of vascular endothelial growth factor receptor signaling pathway [IMP]
- positive regulation vascular endothelial growth factor production [ISO]
- regulation of catalytic activity [IMP]
- regulation of cell proliferation [IMP]
- regulation of gene expression [ISO]
- regulation of glycolytic process [IGI]
- regulation of thymocyte apoptotic process [IGI]
- regulation of transcription from RNA polymerase II promoter [IPI]
- regulation of transcription from RNA polymerase II promoter in response to oxidative stress [IMP, ISO]
- regulation of transcription, DNA-templated [IDA, ISO]
- regulation of transforming growth factor beta2 production [ISO]
- response to fungicide [ISO]
- response to hypoxia [IDA, IGI, IMP, ISO]
- response to muscle activity [IMP]
- retina vasculature development in camera-type eye [IMP]
- signal transduction [ISO]
- transcription from RNA polymerase II promoter [IPI]
- vascular endothelial growth factor production [ISO]
- vasculature development [IGI]
- visual learning [IMP]
Gene Ontology Molecular Function- DNA binding [IDA, IGI]
- Hsp90 protein binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [ISO]
- RNA polymerase II transcription factor binding transcription factor activity [IPI]
- enzyme binding [ISO]
- histone acetyltransferase binding [ISO]
- histone deacetylase binding [IPI]
- nuclear hormone receptor binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein heterodimerization activity [ISO]
- protein kinase binding [ISO]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription factor binding [ISO]
- transcription factor binding transcription factor activity [ISO]
- ubiquitin protein ligase binding [ISO]
- DNA binding [IDA, IGI]
- Hsp90 protein binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [ISO]
- RNA polymerase II transcription factor binding transcription factor activity [IPI]
- enzyme binding [ISO]
- histone acetyltransferase binding [ISO]
- histone deacetylase binding [IPI]
- nuclear hormone receptor binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein heterodimerization activity [ISO]
- protein kinase binding [ISO]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription factor binding [ISO]
- transcription factor binding transcription factor activity [ISO]
- ubiquitin protein ligase binding [ISO]
Mus musculus
PREY
VEGFA
Vegf, Vpf
vascular endothelial growth factor A
GO Process (120)
GO Function (17)
GO Component (7)
Gene Ontology Biological Process
- T-helper 1 type immune response [ISO]
- VEGF-activated neuropilin signaling pathway [IMP]
- activation of protein kinase activity [ISO]
- angiogenesis [IDA, IGI, IMP, ISO]
- angiogenesis involved in coronary vascular morphogenesis [ISO]
- artery morphogenesis [IMP]
- basophil chemotaxis [ISO]
- blood vessel development [IMP]
- blood vessel morphogenesis [IDA, IGI, IMP]
- blood vessel remodeling [ISO]
- branching morphogenesis of an epithelial tube [IDA]
- camera-type eye morphogenesis [IMP]
- cardiac muscle fiber development [IMP]
- cardiac vascular smooth muscle cell development [IMP]
- cell chemotaxis [ISO]
- cell maturation [IMP]
- cell migration [IDA, IGI]
- cell migration involved in sprouting angiogenesis [ISO]
- cell proliferation [IMP]
- cellular response to hypoxia [ISO]
- cellular response to vascular endothelial growth factor stimulus [ISO]
- commissural neuron axon guidance [IDA, IMP]
- coronary artery morphogenesis [IMP]
- coronary vein morphogenesis [IMP]
- dopaminergic neuron differentiation [IGI]
- endothelial cell chemotaxis [ISO]
- endothelial cell migration [IMP]
- epithelial cell differentiation [IMP]
- eye photoreceptor cell development [IMP]
- growth [IMP]
- heart morphogenesis [IMP]
- in utero embryonic development [IMP]
- induction of positive chemotaxis [ISO]
- kidney development [IMP]
- lactation [IMP]
- lung alveolus development [ISO]
- lung development [IDA, IMP]
- lung vasculature development [IDA, IMP]
- lymph vessel morphogenesis [IMP]
- lymphangiogenesis [IGI]
- mRNA stabilization [ISO]
- macrophage differentiation [ISO]
- mammary gland alveolus development [IMP]
- mesoderm development [IMP]
- monocyte differentiation [ISO]
- negative regulation of apoptotic process [IMP, ISO]
- negative regulation of bone resorption [ISO]
- negative regulation of cell-cell adhesion [IGI]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- negative regulation of extrinsic apoptotic signaling pathway [IDA]
- negative regulation of neuron apoptotic process [IDA]
- negative regulation of neuron death [ISO]
- negative regulation of programmed cell death [ISO]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- nervous system development [ISO]
- neuron development [IMP]
- outflow tract morphogenesis [IMP]
- ovarian follicle development [IMP]
- patterning of blood vessels [IMP]
- positive chemotaxis [IDA, ISO]
- positive regulation of CREB transcription factor activity [ISO]
- positive regulation of ERK1 and ERK2 cascade [IDA, ISO]
- positive regulation of MAP kinase activity [ISO]
- positive regulation of angiogenesis [IDA, ISO]
- positive regulation of axon extension involved in axon guidance [IDA, IMP]
- positive regulation of blood vessel endothelial cell migration [ISO]
- positive regulation of branching involved in ureteric bud morphogenesis [IDA]
- positive regulation of cell adhesion [ISO]
- positive regulation of cell migration [ISO]
- positive regulation of cell migration involved in sprouting angiogenesis [ISO]
- positive regulation of cell proliferation [IDA, ISO]
- positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway [ISO]
- positive regulation of cellular component movement [ISO]
- positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway [ISO]
- positive regulation of endothelial cell migration [ISO]
- positive regulation of endothelial cell proliferation [IDA, ISO]
- positive regulation of epithelial cell proliferation [IMP]
- positive regulation of focal adhesion assembly [ISO]
- positive regulation of gene expression [ISO]
- positive regulation of histone deacetylase activity [ISO]
- positive regulation of lymphangiogenesis [IDA]
- positive regulation of mast cell chemotaxis [ISO]
- positive regulation of mesenchymal cell proliferation [IDA]
- positive regulation of neuroblast proliferation [IGI]
- positive regulation of p38MAPK cascade [ISO]
- positive regulation of peptidyl-serine phosphorylation [ISO]
- positive regulation of peptidyl-tyrosine autophosphorylation [ISO]
- positive regulation of peptidyl-tyrosine phosphorylation [IDA, ISO]
- positive regulation of positive chemotaxis [ISO]
- positive regulation of protein autophosphorylation [ISO]
- positive regulation of protein complex assembly [ISO]
- positive regulation of protein kinase B signaling [IDA]
- positive regulation of protein kinase C signaling [ISO]
- positive regulation of protein kinase D signaling [ISO]
- positive regulation of protein localization to early endosome [ISO]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of receptor activity [ISO]
- positive regulation of receptor internalization [ISO]
- positive regulation of retinal ganglion cell axon guidance [IMP]
- positive regulation of signal transduction [ISO]
- positive regulation of smooth muscle cell proliferation [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of transcription from RNA polymerase II promoter in response to hypoxia [ISO]
- positive regulation of vascular endothelial growth factor receptor signaling pathway [ISO]
- positive regulation of vascular permeability [IDA, ISO]
- post-embryonic camera-type eye development [IMP]
- primitive erythrocyte differentiation [IMP]
- regulation of cGMP metabolic process [ISO]
- regulation of cell shape [ISO]
- regulation of endothelial cell differentiation [IDA]
- regulation of hematopoietic progenitor cell differentiation [IDA]
- regulation of retinal ganglion cell axon guidance [IDA, IMP]
- regulation of transcription from RNA polymerase II promoter [ISO]
- response to hypoxia [ISO]
- sprouting angiogenesis [IDA]
- surfactant homeostasis [IMP]
- tube formation [ISO]
- vascular endothelial growth factor receptor signaling pathway [IDA, ISO]
- vascular endothelial growth factor signaling pathway [IDA, ISO]
- vasculature development [IMP]
Gene Ontology Molecular Function- chemoattractant activity [IDA, ISO]
- cytokine activity [ISO]
- extracellular matrix binding [IDA]
- fibronectin binding [ISO]
- growth factor activity [IDA, ISO]
- heparin binding [IDA, ISO]
- identical protein binding [ISO]
- neuropilin binding [ISO]
- platelet-derived growth factor receptor binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [ISO]
- protein homodimerization activity [ISO]
- receptor agonist activity [ISO]
- receptor binding [IDA]
- vascular endothelial growth factor receptor 1 binding [IDA, ISO]
- vascular endothelial growth factor receptor 2 binding [IDA, IPI, ISO]
- vascular endothelial growth factor receptor binding [ISO]
- chemoattractant activity [IDA, ISO]
- cytokine activity [ISO]
- extracellular matrix binding [IDA]
- fibronectin binding [ISO]
- growth factor activity [IDA, ISO]
- heparin binding [IDA, ISO]
- identical protein binding [ISO]
- neuropilin binding [ISO]
- platelet-derived growth factor receptor binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [ISO]
- protein homodimerization activity [ISO]
- receptor agonist activity [ISO]
- receptor binding [IDA]
- vascular endothelial growth factor receptor 1 binding [IDA, ISO]
- vascular endothelial growth factor receptor 2 binding [IDA, IPI, ISO]
- vascular endothelial growth factor receptor binding [ISO]
Gene Ontology Cellular Component
Mus musculus
Co-localization
Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.
Publication
Mouse snail is a target gene for HIF.
The transcriptional inhibitor Snail is a critical regulator for epithelial-mesenchymal transition (EMT). Although low oxygen induces Snail transcription, thereby stimulating EMT, a direct role of hypoxia-inducible factor (HIF) in this process remains to be demonstrated. Here we show that hypoxia induces the expression of Snail via HIF. In silico analysis identified a potential hypoxia-response element (HRE) close to the minimal ... [more]
Mol. Cancer Res. Feb. 01, 2011; 9(2);234-45 [Pubmed: 21257819]
Throughput
- Low Throughput
Additional Notes
- ChIP: VEGF promoter
Curated By
- BioGRID