BAIT
GPSM1
AGS3, RP13-270L15.1
G-protein signaling modulator 1
GO Process (0)
GO Function (0)
GO Component (2)
Gene Ontology Cellular Component
Homo sapiens
PREY
ROBO1
AW494633, AW742721, DUTT1, Gm310
roundabout homolog 1 (Drosophila)
GO Process (15)
GO Function (4)
GO Component (5)
Gene Ontology Biological Process
- Roundabout signaling pathway [ISO]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- axon guidance [IGI, IMP, ISO]
- axon midline choice point recognition [IGI]
- cell migration involved in sprouting angiogenesis [ISO]
- chemorepulsion involved in postnatal olfactory bulb interneuron migration [ISO]
- homophilic cell adhesion via plasma membrane adhesion molecules [ISO]
- mammary duct terminal end bud growth [IMP]
- negative regulation of cell proliferation [IMP]
- negative regulation of chemokine-mediated signaling pathway [ISO]
- negative regulation of mammary gland epithelial cell proliferation [ISO]
- negative regulation of negative chemotaxis [ISO]
- olfactory bulb interneuron development [IGI]
- positive regulation of axonogenesis [ISO]
- regulation of dendrite morphogenesis [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Interaction of activator of G-protein signaling 3 (AGS3) with LKB1, a serine/threonine kinase involved in cell polarity and cell cycle progression: phosphorylation of the G-protein regulatory (GPR) motif as a regulatory mechanism for the interaction of GPR motifs with Gi alpha.
Activator of G-protein signaling 3 (AGS3) has a modular domain structure consisting of seven tetratricopeptide repeats (TPRs) and four G-protein regulatory (GPR) motifs. Each GPR motif binds to the alpha subunit of Gi/Go (Gialpha > Goalpha) stabilizing the GDP-bound conformation of Galpha and apparently competing with Gbetagamma for GalphaGDP binding. As an initial approach to identify regulatory mechanisms for AGS3-G-protein ... [more]
J. Biol. Chem. Jun. 27, 2003; 278(26);23217-20 [Pubmed: 12719437]
Throughput
- High Throughput
Curated By
- BioGRID