STK11
Gene Ontology Biological Process
- Golgi localization [IMP]
- T cell receptor signaling pathway [IGI, IMP]
- TCR signalosome assembly [IMP]
- activation of protein kinase activity [IDA, ISO]
- anoikis [ISO]
- axonogenesis [IMP, ISO]
- canonical Wnt signaling pathway [IMP]
- cell cycle arrest [ISO]
- dendrite extension [IMP]
- establishment of cell polarity [IMP]
- glucose homeostasis [IMP]
- intrinsic apoptotic signaling pathway by p53 class mediator [ISO]
- negative regulation of cell growth [IDA]
- negative regulation of cell proliferation [ISO]
- negative regulation of epithelial cell proliferation involved in prostate gland development [IMP]
- positive regulation of axonogenesis [IGI]
- positive regulation of gluconeogenesis [ISO]
- positive regulation of peptidyl-tyrosine phosphorylation [IMP]
- positive regulation of protein kinase activity [IMP]
- positive regulation of transforming growth factor beta receptor signaling pathway [IMP, ISO]
- positive thymic T cell selection [IMP]
- protein autophosphorylation [IDA, ISO]
- protein heterooligomerization [ISO]
- protein phosphorylation [IMP, ISO]
- regulation of Wnt signaling pathway [IMP]
- regulation of cell growth [IDA]
- regulation of dendrite morphogenesis [IMP]
- regulation of protein kinase B signaling [IMP]
- response to ionizing radiation [IDA]
- response to lipid [ISO]
- spermatid development [IMP]
- tissue homeostasis [IMP]
- vasculature development [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
GPSM1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Interaction of activator of G-protein signaling 3 (AGS3) with LKB1, a serine/threonine kinase involved in cell polarity and cell cycle progression: phosphorylation of the G-protein regulatory (GPR) motif as a regulatory mechanism for the interaction of GPR motifs with Gi alpha.
Activator of G-protein signaling 3 (AGS3) has a modular domain structure consisting of seven tetratricopeptide repeats (TPRs) and four G-protein regulatory (GPR) motifs. Each GPR motif binds to the alpha subunit of Gi/Go (Gialpha > Goalpha) stabilizing the GDP-bound conformation of Galpha and apparently competing with Gbetagamma for GalphaGDP binding. As an initial approach to identify regulatory mechanisms for AGS3-G-protein ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID