STK11
Gene Ontology Biological Process
- Golgi localization [IMP]
- T cell receptor signaling pathway [IGI, IMP]
- TCR signalosome assembly [IMP]
- activation of protein kinase activity [IDA, ISO]
- anoikis [ISO]
- axonogenesis [IMP, ISO]
- canonical Wnt signaling pathway [IMP]
- cell cycle arrest [ISO]
- dendrite extension [IMP]
- establishment of cell polarity [IMP]
- glucose homeostasis [IMP]
- intrinsic apoptotic signaling pathway by p53 class mediator [ISO]
- negative regulation of cell growth [IDA]
- negative regulation of cell proliferation [ISO]
- negative regulation of epithelial cell proliferation involved in prostate gland development [IMP]
- positive regulation of axonogenesis [IGI]
- positive regulation of gluconeogenesis [ISO]
- positive regulation of peptidyl-tyrosine phosphorylation [IMP]
- positive regulation of protein kinase activity [IMP]
- positive regulation of transforming growth factor beta receptor signaling pathway [IMP, ISO]
- positive thymic T cell selection [IMP]
- protein autophosphorylation [IDA, ISO]
- protein heterooligomerization [ISO]
- protein phosphorylation [IMP, ISO]
- regulation of Wnt signaling pathway [IMP]
- regulation of cell growth [IDA]
- regulation of dendrite morphogenesis [IMP]
- regulation of protein kinase B signaling [IMP]
- response to ionizing radiation [IDA]
- response to lipid [ISO]
- spermatid development [IMP]
- tissue homeostasis [IMP]
- vasculature development [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
GPSM1
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Interaction of activator of G-protein signaling 3 (AGS3) with LKB1, a serine/threonine kinase involved in cell polarity and cell cycle progression: phosphorylation of the G-protein regulatory (GPR) motif as a regulatory mechanism for the interaction of GPR motifs with Gi alpha.
Activator of G-protein signaling 3 (AGS3) has a modular domain structure consisting of seven tetratricopeptide repeats (TPRs) and four G-protein regulatory (GPR) motifs. Each GPR motif binds to the alpha subunit of Gi/Go (Gialpha > Goalpha) stabilizing the GDP-bound conformation of Galpha and apparently competing with Gbetagamma for GalphaGDP binding. As an initial approach to identify regulatory mechanisms for AGS3-G-protein ... [more]
Throughput
- Low Throughput
Additional Notes
- Source of GPSM1 not clear
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| STK11 GPSM1 | Biochemical Activity Biochemical Activity An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation. | Low | - | BioGRID | 2497978 | |
| GPSM1 STK11 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | High | - | BioGRID | - |
Curated By
- BioGRID