An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.

Publication

RioK1, a new interactor of protein arginine methyltransferase 5 (PRMT5), competes with pICln for binding and modulates PRMT5 complex composition and substrate specificity.

Guderian G, Peter C, Wiesner J, Sickmann A, Schulze-Osthoff K, Fischer U, Grimmler M

Protein arginine methylation plays a critical role in differential gene expression through modulating protein-protein and protein-DNA/RNA interactions. Although numerous proteins undergo arginine methylation, only limited information is available on how protein arginine methyltransferases (PRMTs) identify their substrates. The human PRMT5 complex consists of PRMT5, WD45/MEP50 (WD repeat domain 45/methylosome protein 50), and pICln and catalyzes the symmetrical arginine dimethylation of ... [more]

J. Biol. Chem. Jan. 21, 2011; 286(3);1976-86 [Pubmed: 21081503]

Throughput

Low Throughput

Curated By

BioGRID

Interaction Summary

PRMT5

Gene Ontology Biological Process

Gene Ontology Molecular Function

core promoter sequence-specific DNA binding [ISS]histone-arginine N-methyltransferase activity [IBA]methyltransferase activity [IDA]protein binding [IPI]protein-arginine omega-N symmetric methyltransferase activity [IMP]ribonucleoprotein complex binding [IPI]transcription corepressor activity [ISS]

Gene Ontology Cellular Component

ILF3