BAIT

RNG3

SPCC613.04c
UCS-domain protein Rng3
GO Process (2)
GO Function (2)
GO Component (5)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Schizosaccharomyces pombe (972h)
PREY

HSP90

git10, swo1, SPAC926.04c
Hsp90 chaperone
Schizosaccharomyces pombe (972h)

Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

Hsp90 protein in fission yeast Swo1p and UCS protein Rng3p facilitate myosin II assembly and function.

Mishra M, D'souza VM, Chang KC, Huang Y, Balasubramanian MK

The F-actin-based molecular motor myosin II is involved in a variety of cellular processes such as muscle contraction, cell motility, and cytokinesis. In recent years, a family of myosin II-specific cochaperones of the UCS family has been identified from work with yeasts, fungi, worms, and humans. Biochemical analyses have shown that a complex of Hsp90 and the Caenorhabditis elegans UCS ... [more]

Eukaryotic Cell Mar. 01, 2005; 4(3);567-76 [Pubmed: 15755919]

Throughput

  • Low Throughput

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
HSP90 RNG3
Synthetic Lethality
Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Low-BioGRID
247991

Curated By

  • BioGRID