BAIT
NR1H4
BAR, FXR, HRR-1, HRR1, RIP14
nuclear receptor subfamily 1, group H, member 4
GO Process (15)
GO Function (13)
GO Component (2)
Gene Ontology Biological Process
- cellular response to bile acid [ISS]
- cellular response to organonitrogen compound [ISS]
- gene expression [TAS]
- intracellular bile acid receptor signaling pathway [IDA]
- intracellular receptor signaling pathway [ISS]
- negative regulation of bile acid biosynthetic process [IDA]
- negative regulation of transcription from RNA polymerase II promoter [ISS]
- nitrogen catabolite activation of transcription from RNA polymerase II promoter [IC]
- positive regulation of glutamate metabolic process [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- regulation of bile acid biosynthetic process [TAS]
- regulation of cholesterol metabolic process [TAS]
- regulation of urea metabolic process [ISS]
- signal transduction [TAS]
- transcription initiation from RNA polymerase II promoter [TAS]
Gene Ontology Molecular Function- RNA polymerase II distal enhancer sequence-specific DNA binding [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA]
- RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription [IDA]
- bile acid binding [ISS, TAS]
- bile acid receptor activity [IDA]
- chenodeoxycholic acid binding [IDA]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [ISS]
- ligand-dependent nuclear receptor binding [TAS]
- protein binding [IPI]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [TAS]
- transcription coactivator activity [TAS]
- transcription corepressor activity [TAS]
- RNA polymerase II distal enhancer sequence-specific DNA binding [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA]
- RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription [IDA]
- bile acid binding [ISS, TAS]
- bile acid receptor activity [IDA]
- chenodeoxycholic acid binding [IDA]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [ISS]
- ligand-dependent nuclear receptor binding [TAS]
- protein binding [IPI]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [TAS]
- transcription coactivator activity [TAS]
- transcription corepressor activity [TAS]
Gene Ontology Cellular Component
Homo sapiens
PREY
NCOA1
F-SRC-1, KAT13A, RIP160, SRC1, bHLHe42, bHLHe74
nuclear receptor coactivator 1
GO Process (9)
GO Function (9)
GO Component (2)
Gene Ontology Biological Process
- androgen receptor signaling pathway [NAS]
- cellular lipid metabolic process [TAS]
- cellular response to hormone stimulus [IBA]
- intracellular receptor signaling pathway [IBA]
- positive regulation of transcription from RNA polymerase II promoter [IDA, NAS]
- positive regulation of transcription from RNA polymerase II promoter by galactose [IDA]
- positive regulation of transcription, DNA-templated [IDA, NAS]
- small molecule metabolic process [TAS]
- transcription, DNA-templated [IDA]
Gene Ontology Molecular Function- RNA polymerase II transcription coactivator activity [NAS]
- androgen receptor binding [NAS]
- enzyme binding [IPI]
- ligand-dependent nuclear receptor binding [IPI]
- ligand-dependent nuclear receptor transcription coactivator activity [IDA]
- nuclear hormone receptor binding [IDA]
- protein N-terminus binding [IPI]
- protein binding [IPI]
- transcription coactivator activity [IDA, NAS]
- RNA polymerase II transcription coactivator activity [NAS]
- androgen receptor binding [NAS]
- enzyme binding [IPI]
- ligand-dependent nuclear receptor binding [IPI]
- ligand-dependent nuclear receptor transcription coactivator activity [IDA]
- nuclear hormone receptor binding [IDA]
- protein N-terminus binding [IPI]
- protein binding [IPI]
- transcription coactivator activity [IDA, NAS]
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Correlation of farnesoid X receptor coactivator recruitment and cholesterol 7alpha-hydroxylase gene repression by bile acids.
Cholesterol conversion to bile acids in the liver is regulated by the rate-limiting enzyme cholesterol 7alpha-hydroxylase (CYP7A1). CYP7A1 activity is regulated by feedback repression by bile acids at the transcriptional level. The farnesoid X receptor (FXR), a member of the nuclear hormone receptor superfamily, was recently demonstrated to function as the bile acid receptor and its high level of expression ... [more]
Mol. Genet. Metab. Dec. 01, 2000; 71(4);609-15 [Pubmed: 11136553]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| NCOA1 NR1H4 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - |
Curated By
- BioGRID