BAIT

RNF146

dJ351K20.1, RP3-351K20.1
ring finger protein 146
UPS Project
Homo sapiens
PREY

MPDZ

HYC2, MUPP1, RP11-382H24.1
multiple PDZ domain protein
Human Papilloma Virus (HPV) Project
GO Process (0)
GO Function (2)
GO Component (2)

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens

Proximity Label-MS

An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.

Publication

The RNF146 and tankyrase pathway maintains the junctional Crumbs complex through regulation of angiomotin.

Campbell CI, Samavarchi-Tehrani P, Barrios-Rodiles M, Datti A, Gingras AC, Wrana JL

The Crumbs complex is an important determinant of epithelial apical-basal polarity that functions in regulation of tight junctions, resistance to epithelial-to-mesenchymal transitions and as a tumour suppressor. Although the functional role of the Crumbs complex is being elucidated, its regulation is poorly understood. Here, we show that suppression of RNF146, an E3 ubiquitin ligase that recognizes ADP-ribosylated substrates, and tankyrase, ... [more]

J. Cell. Sci. Sep. 15, 2016; 129(18);3396-411 [Pubmed: 27521426]

Throughput

  • High Throughput

Curated By

  • BioGRID