Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.

Publication

HRS-WASH axis governs actin-mediated endosomal recycling and cell invasion.

MacDonald E, Brown L, Selvais A, Liu H, Waring T, Newman D, Bithell J, Grimes D, Urbe S, Clague MJ, Zech T

Transmembrane proteins in the sorting endosome are either recycled to their point of origin or destined for lysosomal degradation. Lysosomal sorting is mediated by interaction of ubiquitylated transmembrane proteins with the endosomal sorting complex required for transport (ESCRT) machinery. In this study, we uncover an alternative role for the ESCRT-0 component hepatocyte growth factor-regulated tyrosine kinase substrate (HRS) in promoting ... [more]

J. Cell Biol. Jul. 02, 2018; 217(7);2549-2564 [Pubmed: 29891722]

Throughput

Low Throughput

Curated By

BioGRID

Interaction Summary

EEA1

Gene Ontology Biological Process

Gene Ontology Molecular Function

1-phosphatidylinositol binding [IDA]GTP-dependent protein binding [IDA]calmodulin binding [NAS]protein binding [IPI]protein homodimerization activity [IDA]zinc ion binding [TAS]

Gene Ontology Cellular Component

VPS35

Gene Ontology Biological Process

Gene Ontology Molecular Function

protein binding [IPI]protein transporter activity [IBA]

Gene Ontology Cellular Component

Co-localization

Publication

HRS-WASH axis governs actin-mediated endosomal recycling and cell invasion.

Throughput

Curated By

1-phosphatidylinositol binding [IDA]
GTP-dependent protein binding [IDA]
calmodulin binding [NAS]
protein binding [IPI]
protein homodimerization activity [IDA]
zinc ion binding [TAS]

protein binding [IPI]
protein transporter activity [IBA]