BAIT
ITM2B
Bri, imBRI2
integral membrane protein 2B
GO Process (2)
GO Function (2)
GO Component (8)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
HSPD1
Hsp60, Hspd1-30p
heat shock protein 1 (chaperonin)
GO Process (35)
GO Function (12)
GO Component (23)
Gene Ontology Biological Process
- 'de novo' protein folding [IC]
- B cell activation [ISO]
- B cell cytokine production [ISO]
- B cell proliferation [ISO]
- MyD88-dependent toll-like receptor signaling pathway [ISO]
- T cell activation [ISO]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- chaperone mediated protein folding requiring cofactor [IDA]
- detection of misfolded protein [IDA]
- isotype switching to IgG isotypes [ISO]
- negative regulation of apoptotic process [IMP, ISO]
- negative regulation of neuron apoptotic process [IMP]
- positive regulation of T cell activation [ISO]
- positive regulation of T cell mediated immune response to tumor cell [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of inflammatory response [IDA]
- positive regulation of interferon-alpha production [ISO]
- positive regulation of interferon-gamma production [ISO]
- positive regulation of interleukin-10 production [ISO]
- positive regulation of interleukin-12 production [ISO]
- positive regulation of interleukin-6 production [ISO]
- positive regulation of macrophage activation [ISO]
- protein refolding [ISO]
- protein stabilization [ISO]
- response to ATP [IEP]
- response to cocaine [IEP]
- response to drug [IEP]
- response to estrogen [IEP]
- response to heat [IEP]
- response to hydrogen peroxide [IEP]
- response to hypoxia [IEP]
- response to lipopolysaccharide [IEP]
- response to organic cyclic compound [IEP]
- response to organic substance [IEP]
- response to unfolded protein [ISO]
Gene Ontology Molecular Function- chaperone binding [ISO]
- double-stranded RNA binding [ISO]
- insulin binding [IPI]
- lipopolysaccharide binding [ISO]
- misfolded protein binding [IPI]
- p53 binding [ISO]
- poly(A) RNA binding [ISO]
- protease binding [IPI]
- protein binding [IPI]
- protein complex binding [IPI]
- protein heterodimerization activity [IPI]
- ubiquitin protein ligase binding [ISO]
- chaperone binding [ISO]
- double-stranded RNA binding [ISO]
- insulin binding [IPI]
- lipopolysaccharide binding [ISO]
- misfolded protein binding [IPI]
- p53 binding [ISO]
- poly(A) RNA binding [ISO]
- protease binding [IPI]
- protein binding [IPI]
- protein complex binding [IPI]
- protein heterodimerization activity [IPI]
- ubiquitin protein ligase binding [ISO]
Gene Ontology Cellular Component
- Golgi apparatus [IDA]
- cell surface [IDA, ISO]
- coated pit [ISO]
- coated vesicle [ISO]
- cyclin-dependent protein kinase activating kinase holoenzyme complex [ISO]
- cytoplasm [IDA, ISO]
- cytosol [IDA, ISO]
- early endosome [ISO]
- extracellular space [ISO]
- extracellular vesicular exosome [ISO]
- intracellular membrane-bounded organelle [ISO]
- lipopolysaccharide receptor complex [ISO]
- membrane [ISO]
- membrane raft [IDA]
- mitochondrial crista [IDA]
- mitochondrial inner membrane [ISO]
- mitochondrion [IDA, ISO]
- myelin sheath [ISO]
- plasma membrane [ISO]
- protein complex [ISO, ISS]
- rough endoplasmic reticulum [IDA]
- secretory granule [IDA, ISO]
- zymogen granule [IDA]
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Identification and characterization of the BRI2 interactome in the brain.
BRI family proteins are ubiquitous type II transmembrane proteins but BRI2 is highly expressed in some neuronal tissues. Possible BRI2 functions include neuronal maturation and differentiation. Protein complexes appear to be important in mediating its functions. Previously described BRI2 interactors include the Alzheimer's amyloid precursor protein and protein phosphatase 1, but clearly the identification of novel interactors provides an important ... [more]
Sci Rep Feb. 23, 2018; 8(1);3548 [Pubmed: 29476059]
Throughput
- High Throughput
Curated By
- BioGRID