BAIT
ITM2B
Bri, imBRI2
integral membrane protein 2B
GO Process (2)
GO Function (2)
GO Component (8)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
ANK3
ANK-3
ankyrin 3, node of Ranvier (ankyrin G)
GO Process (23)
GO Function (7)
GO Component (25)
Gene Ontology Biological Process
- Golgi to plasma membrane protein transport [ISO]
- axon guidance [ISO]
- axonogenesis [ISO]
- establishment of protein localization [ISO]
- maintenance of protein location in plasma membrane [ISO]
- membrane assembly [IGI, ISO]
- mitotic cytokinesis [ISO]
- neuromuscular junction development [IEP]
- neuronal action potential [ISO]
- plasma membrane organization [ISO]
- positive regulation of cation channel activity [IMP]
- positive regulation of cell communication by electrical coupling [IMP]
- positive regulation of gene expression [IMP]
- positive regulation of homotypic cell-cell adhesion [IMP]
- positive regulation of membrane depolarization during cardiac muscle cell action potential [IMP]
- positive regulation of membrane potential [IMP]
- positive regulation of protein targeting to membrane [IMP]
- positive regulation of sodium ion transmembrane transporter activity [IMP]
- positive regulation of sodium ion transport [IMP]
- protein localization to plasma membrane [IGI, IMP, ISO]
- protein targeting to plasma membrane [ISO]
- regulation of potassium ion transport [IDA]
- synapse organization [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- T-tubule [IDA]
- Z disc [IDA]
- axon [ISO]
- axon initial segment [IDA, ISO]
- basal plasma membrane [ISO]
- basolateral plasma membrane [ISO]
- cell [ISO]
- cell surface [IDA]
- costamere [TAS]
- dendrite [IDA]
- intercalated disc [IDA, ISO]
- intracellular [ISO]
- lateral plasma membrane [ISO]
- membrane [ISO]
- neuromuscular junction [IDA]
- neuron projection [IDA]
- node of Ranvier [IDA, ISO]
- paranode region of axon [ISO]
- plasma membrane [IDA]
- postsynaptic membrane [IDA]
- sarcolemma [IDA, ISO]
- sarcoplasmic reticulum [IDA]
- spectrin-associated cytoskeleton [IDA]
- synapse [ISO]
- tight junction [ISO]
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Identification and characterization of the BRI2 interactome in the brain.
BRI family proteins are ubiquitous type II transmembrane proteins but BRI2 is highly expressed in some neuronal tissues. Possible BRI2 functions include neuronal maturation and differentiation. Protein complexes appear to be important in mediating its functions. Previously described BRI2 interactors include the Alzheimer's amyloid precursor protein and protein phosphatase 1, but clearly the identification of novel interactors provides an important ... [more]
Sci Rep Feb. 23, 2018; 8(1);3548 [Pubmed: 29476059]
Throughput
- High Throughput
Curated By
- BioGRID