BAIT
ITM2B
Bri, imBRI2
integral membrane protein 2B
GO Process (2)
GO Function (2)
GO Component (8)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
ARRB1
BARRES
arrestin, beta 1
GO Process (40)
GO Function (22)
GO Component (13)
Gene Ontology Biological Process
- G-protein coupled receptor internalization [ISO]
- G-protein coupled receptor signaling pathway [IDA]
- activation of MAPK activity [IDA]
- adenylate cyclase-modulating G-protein coupled receptor signaling pathway [TAS]
- desensitization of G-protein coupled receptor protein signaling pathway by arrestin [TAS]
- endocytosis [IDA]
- follicle-stimulating hormone signaling pathway [IDA]
- negative regulation of ERK1 and ERK2 cascade [IMP]
- negative regulation of GTPase activity [IDA]
- negative regulation of NF-kappaB transcription factor activity [ISO]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- negative regulation of interleukin-6 production [ISO]
- negative regulation of interleukin-8 production [ISO]
- negative regulation of protein phosphorylation [IMP]
- negative regulation of protein ubiquitination [ISO]
- phototransduction [ISO]
- positive regulation of ERK1 and ERK2 cascade [IMP, ISO]
- positive regulation of GTPase activity [ISO]
- positive regulation of Rho protein signal transduction [ISO]
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [IMP]
- positive regulation of histone H4 acetylation [ISO]
- positive regulation of histone acetylation [ISO]
- positive regulation of insulin secretion involved in cellular response to glucose stimulus [ISO]
- positive regulation of peptidyl-serine phosphorylation [ISO]
- positive regulation of protein binding [ISO]
- positive regulation of protein phosphorylation [ISO, ISS]
- positive regulation of protein ubiquitination [IMP]
- positive regulation of receptor internalization [ISO, ISS]
- positive regulation of smooth muscle cell apoptotic process [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, ISO]
- proteasome-mediated ubiquitin-dependent protein catabolic process [ISO]
- protein ubiquitination [ISO]
- receptor-mediated endocytosis [IDA]
- regulation of G-protein coupled receptor protein signaling pathway [IDA, ISO, TAS]
- regulation of cAMP biosynthetic process [TAS]
- regulation of cAMP catabolic process [TAS]
- sensory perception of pain [TAS]
- sensory perception of touch [TAS]
- stress fiber assembly [ISO]
- transcription from RNA polymerase II promoter [IDA, ISO]
Gene Ontology Molecular Function- AP-2 adaptor complex binding [IDA]
- G-protein coupled receptor binding [TAS]
- GTPase activator activity [ISO]
- V2 vasopressin receptor binding [IMP]
- alpha-1A adrenergic receptor binding [IPI]
- alpha-1B adrenergic receptor binding [IDA]
- angiotensin receptor binding [ISO]
- clathrin adaptor activity [IDA]
- clathrin binding [TAS]
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process [ISO]
- estrogen receptor binding [IPI]
- follicle-stimulating hormone receptor binding [IPI]
- histone acetyltransferase activity [ISO]
- insulin-like growth factor receptor binding [ISO]
- ion channel binding [IPI]
- mitogen-activated protein kinase kinase binding [ISO]
- phosphoprotein binding [IPI]
- protein binding [IPI]
- protein phosphorylated amino acid binding [IMP]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [ISO]
- ubiquitin protein ligase binding [ISO]
- AP-2 adaptor complex binding [IDA]
- G-protein coupled receptor binding [TAS]
- GTPase activator activity [ISO]
- V2 vasopressin receptor binding [IMP]
- alpha-1A adrenergic receptor binding [IPI]
- alpha-1B adrenergic receptor binding [IDA]
- angiotensin receptor binding [ISO]
- clathrin adaptor activity [IDA]
- clathrin binding [TAS]
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process [ISO]
- estrogen receptor binding [IPI]
- follicle-stimulating hormone receptor binding [IPI]
- histone acetyltransferase activity [ISO]
- insulin-like growth factor receptor binding [ISO]
- ion channel binding [IPI]
- mitogen-activated protein kinase kinase binding [ISO]
- phosphoprotein binding [IPI]
- protein binding [IPI]
- protein phosphorylated amino acid binding [IMP]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [ISO]
- ubiquitin protein ligase binding [ISO]
Gene Ontology Cellular Component
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Identification and characterization of the BRI2 interactome in the brain.
BRI family proteins are ubiquitous type II transmembrane proteins but BRI2 is highly expressed in some neuronal tissues. Possible BRI2 functions include neuronal maturation and differentiation. Protein complexes appear to be important in mediating its functions. Previously described BRI2 interactors include the Alzheimer's amyloid precursor protein and protein phosphatase 1, but clearly the identification of novel interactors provides an important ... [more]
Sci Rep Feb. 23, 2018; 8(1);3548 [Pubmed: 29476059]
Throughput
- High Throughput
Curated By
- BioGRID