BAIT
ITM2B
Bri, imBRI2
integral membrane protein 2B
GO Process (2)
GO Function (2)
GO Component (8)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
CAMK2D
CAMK1, Camk2, Camki, RATCAMKI
calcium/calmodulin-dependent protein kinase II delta
GO Process (33)
GO Function (9)
GO Component (13)
Gene Ontology Biological Process
- G1/S transition of mitotic cell cycle [ISO]
- calcium ion transport [ISO]
- cardiac muscle cell contraction [IDA]
- cardiac muscle contraction [ISO]
- cell growth involved in cardiac muscle cell development [IMP]
- cellular potassium ion homeostasis [IMP]
- endoplasmic reticulum calcium ion homeostasis [IDA]
- negative regulation of sodium ion transmembrane transport [ISO]
- negative regulation of sodium ion transmembrane transporter activity [ISO]
- peptidyl-serine phosphorylation [IDA, ISO]
- peptidyl-threonine phosphorylation [IDA, ISO]
- positive regulation of ERK1 and ERK2 cascade [IMP]
- positive regulation of Rac protein signal transduction [IMP]
- positive regulation of cardiac muscle hypertrophy [ISO, ISS]
- positive regulation of smooth muscle cell migration [IMP]
- positive regulation of smooth muscle cell proliferation [IMP]
- protein autophosphorylation [IDA, ISO]
- protein oligomerization [ISO]
- protein phosphorylation [IDA, ISO, ISS]
- regulation of G2/M transition of mitotic cell cycle [IMP]
- regulation of cardiac muscle cell action potential [IDA]
- regulation of cardiac muscle cell action potential involved in regulation of contraction [IC]
- regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [IC]
- regulation of cell communication by electrical coupling [IDA]
- regulation of cell communication by electrical coupling involved in cardiac conduction [IC]
- regulation of cellular localization [ISO, ISS]
- regulation of generation of L-type calcium current [IDA]
- regulation of membrane depolarization [ISO]
- regulation of relaxation of cardiac muscle [IDA, ISO]
- regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [IDA]
- regulation of sodium ion transport [ISO]
- relaxation of cardiac muscle [IDA]
- response to hypoxia [IMP]
Gene Ontology Molecular Function- calmodulin binding [ISO]
- calmodulin-dependent protein kinase activity [IDA, IMP, ISO]
- ion channel binding [IDA, IPI, ISO]
- nitric-oxide synthase binding [IPI]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- protein serine/threonine kinase activity [ISO]
- sodium channel inhibitor activity [ISO]
- titin binding [ISO]
- calmodulin binding [ISO]
- calmodulin-dependent protein kinase activity [IDA, IMP, ISO]
- ion channel binding [IDA, IPI, ISO]
- nitric-oxide synthase binding [IPI]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- protein serine/threonine kinase activity [ISO]
- sodium channel inhibitor activity [ISO]
- titin binding [ISO]
Gene Ontology Cellular Component
- T-tubule [ISO]
- axon initial segment [ISO]
- calcium channel complex [IDA, ISO]
- cytoplasm [IDA, ISO]
- cytosol [IDA]
- intercalated disc [ISO]
- membrane [ISO]
- neuromuscular junction [ISO]
- neuronal cell body [ISO]
- nucleus [IDA, ISO]
- perinuclear region of cytoplasm [IDA]
- protein complex [IDA]
- sarcoplasmic reticulum [ISO]
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Identification and characterization of the BRI2 interactome in the brain.
BRI family proteins are ubiquitous type II transmembrane proteins but BRI2 is highly expressed in some neuronal tissues. Possible BRI2 functions include neuronal maturation and differentiation. Protein complexes appear to be important in mediating its functions. Previously described BRI2 interactors include the Alzheimer's amyloid precursor protein and protein phosphatase 1, but clearly the identification of novel interactors provides an important ... [more]
Sci Rep Feb. 23, 2018; 8(1);3548 [Pubmed: 29476059]
Throughput
- High Throughput
Curated By
- BioGRID