BAIT
ITM2B
Bri, imBRI2
integral membrane protein 2B
GO Process (2)
GO Function (2)
GO Component (8)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
CALM1
CaMI, rCG_20808
calmodulin 1
GO Process (21)
GO Function (19)
GO Component (14)
Gene Ontology Biological Process
- G2/M transition of mitotic cell cycle [ISO]
- activation of adenylate cyclase activity [IDA]
- calcium-mediated signaling [IMP]
- detection of calcium ion [ISO]
- positive regulation of DNA binding [ISO]
- positive regulation of cyclic nucleotide metabolic process [ISO]
- positive regulation of cyclic-nucleotide phosphodiesterase activity [ISO]
- positive regulation of nitric-oxide synthase activity [IDA]
- positive regulation of phosphoprotein phosphatase activity [ISO]
- positive regulation of protein dephosphorylation [ISO]
- positive regulation of ryanodine-sensitive calcium-release channel activity [ISO]
- regulation of cardiac muscle contraction [ISO]
- regulation of cytokinesis [ISO]
- regulation of heart rate [ISO]
- regulation of high voltage-gated calcium channel activity [IMP]
- regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [ISO]
- regulation of ryanodine-sensitive calcium-release channel activity [IDA]
- regulation of store-operated calcium channel activity [IC]
- response to amphetamine [IEP]
- response to calcium ion [ISO]
- substantia nigra development [ISO]
Gene Ontology Molecular Function- N-terminal myristoylation domain binding [ISO]
- adenylate cyclase binding [IDA]
- calcium channel regulator activity [NAS]
- calcium ion binding [IDA, ISO]
- calcium-dependent protein binding [IPI]
- enzyme regulator activity [IMP]
- ion channel binding [IDA, ISO]
- nitric-oxide synthase binding [IDA]
- nitric-oxide synthase regulator activity [IDA]
- phosphatidylinositol 3-kinase binding [IPI]
- phospholipase binding [ISO]
- protein N-terminus binding [IMP]
- protein binding [IPI]
- protein domain specific binding [IPI, ISO]
- protein kinase binding [ISO]
- protein phosphatase activator activity [ISO]
- thioesterase binding [ISO]
- titin binding [ISO]
- type 3 metabotropic glutamate receptor binding [IPI]
- N-terminal myristoylation domain binding [ISO]
- adenylate cyclase binding [IDA]
- calcium channel regulator activity [NAS]
- calcium ion binding [IDA, ISO]
- calcium-dependent protein binding [IPI]
- enzyme regulator activity [IMP]
- ion channel binding [IDA, ISO]
- nitric-oxide synthase binding [IDA]
- nitric-oxide synthase regulator activity [IDA]
- phosphatidylinositol 3-kinase binding [IPI]
- phospholipase binding [ISO]
- protein N-terminus binding [IMP]
- protein binding [IPI]
- protein domain specific binding [IPI, ISO]
- protein kinase binding [ISO]
- protein phosphatase activator activity [ISO]
- thioesterase binding [ISO]
- titin binding [ISO]
- type 3 metabotropic glutamate receptor binding [IPI]
Gene Ontology Cellular Component
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Identification and characterization of the BRI2 interactome in the brain.
BRI family proteins are ubiquitous type II transmembrane proteins but BRI2 is highly expressed in some neuronal tissues. Possible BRI2 functions include neuronal maturation and differentiation. Protein complexes appear to be important in mediating its functions. Previously described BRI2 interactors include the Alzheimer's amyloid precursor protein and protein phosphatase 1, but clearly the identification of novel interactors provides an important ... [more]
Sci Rep Feb. 23, 2018; 8(1);3548 [Pubmed: 29476059]
Throughput
- High Throughput
Curated By
- BioGRID