BAIT
ITM2B
Bri, imBRI2
integral membrane protein 2B
GO Process (2)
GO Function (2)
GO Component (8)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
CDK5
cyclin-dependent kinase 5
GO Process (70)
GO Function (13)
GO Component (18)
Gene Ontology Biological Process
- Schwann cell development [ISO]
- apoptotic process [ISO]
- associative learning [ISO]
- axon extension [TAS]
- axonogenesis [ISO]
- behavioral response to cocaine [ISO]
- calcium ion import [ISO]
- cell migration [ISO]
- cell-matrix adhesion [ISO]
- central nervous system development [TAS]
- central nervous system neuron development [ISO]
- cerebellar cortex development [ISO]
- cerebellar cortex formation [ISO]
- cerebellum development [ISO]
- cerebral cortex development [ISO]
- corpus callosum development [ISO]
- cortical actin cytoskeleton organization [IMP]
- dendrite morphogenesis [ISO]
- exocytosis [IMP]
- forebrain development [ISO]
- hippocampus development [ISO]
- intracellular protein transport [ISO]
- layer formation in cerebral cortex [ISO]
- motor neuron axon guidance [ISO]
- negative regulation of axon extension [ISO]
- negative regulation of cell cycle [ISO]
- negative regulation of neuron death [ISO]
- negative regulation of protein export from nucleus [ISO]
- negative regulation of protein ubiquitination [ISO]
- negative regulation of proteolysis [ISO]
- negative regulation of synaptic plasticity [ISO]
- negative regulation of transcription, DNA-templated [ISO]
- neuron apoptotic process [IMP, ISO]
- neuron differentiation [IDA, ISO]
- neuron migration [ISO]
- neuron projection development [IMP]
- neuron projection morphogenesis [IMP]
- nucleocytoplasmic transport [IMP]
- oligodendrocyte differentiation [ISO]
- peptidyl-serine phosphorylation [IDA, ISO]
- peptidyl-threonine phosphorylation [ISO]
- phosphorylation [ISO]
- positive regulation of calcium ion-dependent exocytosis [ISO]
- positive regulation of neuron apoptotic process [IDA]
- positive regulation of protein binding [ISO]
- positive regulation of protein kinase activity [ISO]
- positive regulation of protein targeting to membrane [ISO]
- positive regulation of receptor activity [ISO]
- protein autophosphorylation [IDA]
- protein localization to synapse [ISO]
- protein phosphorylation [IDA, ISO]
- receptor catabolic process [ISO]
- receptor clustering [ISO]
- regulated secretory pathway [IMP]
- regulation of cell migration [ISO]
- regulation of dendritic spine morphogenesis [ISO, ISS]
- regulation of excitatory postsynaptic membrane potential [ISO]
- regulation of postsynaptic membrane potential [ISO]
- regulation of synaptic plasticity [IMP]
- response to cocaine [ISO]
- response to wounding [IMP]
- sensory perception of pain [ISO]
- serine phosphorylation of STAT3 protein [ISO]
- skeletal muscle tissue development [IEP, ISO, TAS]
- synapse assembly [ISO]
- synaptic transmission, dopaminergic [ISO]
- synaptic transmission, glutamatergic [ISO]
- synaptic vesicle endocytosis [IMP]
- telencephalon development [ISO]
- visual learning [ISO]
Gene Ontology Molecular Function- ErbB-2 class receptor binding [ISO, ISS]
- ErbB-3 class receptor binding [ISO, ISS]
- acetylcholine receptor activator activity [ISO, ISS]
- cyclin-dependent protein serine/threonine kinase activity [IDA]
- cytoskeletal protein binding [IPI]
- ephrin receptor binding [IPI]
- kinase activity [IDA]
- p53 binding [ISO]
- protein binding [IPI]
- protein kinase activity [IDA, ISO]
- protein kinase binding [IPI]
- protein serine/threonine kinase activity [IDA, ISO]
- tau-protein kinase activity [IDA]
- ErbB-2 class receptor binding [ISO, ISS]
- ErbB-3 class receptor binding [ISO, ISS]
- acetylcholine receptor activator activity [ISO, ISS]
- cyclin-dependent protein serine/threonine kinase activity [IDA]
- cytoskeletal protein binding [IPI]
- ephrin receptor binding [IPI]
- kinase activity [IDA]
- p53 binding [ISO]
- protein binding [IPI]
- protein kinase activity [IDA, ISO]
- protein kinase binding [IPI]
- protein serine/threonine kinase activity [IDA, ISO]
- tau-protein kinase activity [IDA]
Gene Ontology Cellular Component
- axon [IDA, ISO]
- cell [ISO]
- cell junction [TAS]
- cyclin-dependent protein kinase 5 holoenzyme complex [IDA]
- cytoplasm [IDA, ISO]
- cytoskeleton [IDA]
- cytosol [ISO]
- dendrite [IDA]
- filopodium [ISO]
- growth cone [IDA]
- intracellular [ISO]
- lamellipodium [ISO]
- membrane [IDA]
- neuromuscular junction [IDA]
- neuronal cell body [IDA]
- nucleolus [ISO]
- nucleus [IDA, ISO]
- postsynaptic density [IDA]
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Identification and characterization of the BRI2 interactome in the brain.
BRI family proteins are ubiquitous type II transmembrane proteins but BRI2 is highly expressed in some neuronal tissues. Possible BRI2 functions include neuronal maturation and differentiation. Protein complexes appear to be important in mediating its functions. Previously described BRI2 interactors include the Alzheimer's amyloid precursor protein and protein phosphatase 1, but clearly the identification of novel interactors provides an important ... [more]
Sci Rep Feb. 23, 2018; 8(1);3548 [Pubmed: 29476059]
Throughput
- High Throughput
Curated By
- BioGRID