BAIT
ITM2B
Bri, imBRI2
integral membrane protein 2B
GO Process (2)
GO Function (2)
GO Component (8)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
MAP2K1
Mek1
mitogen activated protein kinase kinase 1
GO Process (35)
GO Function (9)
GO Component (18)
Gene Ontology Biological Process
- Golgi inheritance [IMP]
- MAPK cascade [IMP, ISO]
- activation of MAPK activity [IDA, ISO, TAS]
- cell cycle arrest [ISO]
- cell motility [ISO]
- cell proliferation [IDA]
- cellular senescence [ISO]
- intracellular signal transduction [TAS]
- keratinocyte differentiation [ISO]
- labyrinthine layer development [ISO]
- melanosome transport [IDA]
- mitotic nuclear division [IDA]
- negative regulation of cell proliferation [ISO]
- negative regulation of homotypic cell-cell adhesion [IMP]
- neuron differentiation [IMP, ISO]
- neuron projection morphogenesis [IMP]
- peptidyl-tyrosine dephosphorylation [ISO]
- placenta blood vessel development [ISO]
- positive regulation of Ras GTPase activity [IMP]
- positive regulation of Ras protein signal transduction [IMP]
- positive regulation of cell differentiation [ISO]
- positive regulation of cell migration [IMP]
- positive regulation of gene expression [ISO]
- positive regulation of protein serine/threonine kinase activity [ISO]
- positive regulation of transcription elongation from RNA polymerase II promoter [IMP]
- protein heterooligomerization [IPI]
- protein phosphorylation [IDA, ISO, TAS]
- regulation of Golgi inheritance [TAS]
- regulation of early endosome to late endosome transport [TAS]
- regulation of stress-activated MAPK cascade [TAS]
- regulation of vascular smooth muscle contraction [IMP]
- response to axon injury [IMP]
- response to glucocorticoid [IDA]
- response to oxidative stress [IDA]
- vesicle transport along microtubule [IDA]
Gene Ontology Molecular Function- ATP binding [IDA]
- MAP kinase kinase activity [IDA, IMP, ISO, TAS]
- Ras GTPase binding [IPI]
- mitogen-activated protein kinase kinase kinase binding [IDA, IPI]
- protein binding [IPI]
- protein kinase binding [IPI]
- protein serine/threonine kinase activator activity [ISO]
- protein serine/threonine/tyrosine kinase activity [TAS]
- receptor signaling protein tyrosine phosphatase activity [ISO]
- ATP binding [IDA]
- MAP kinase kinase activity [IDA, IMP, ISO, TAS]
- Ras GTPase binding [IPI]
- mitogen-activated protein kinase kinase kinase binding [IDA, IPI]
- protein binding [IPI]
- protein kinase binding [IPI]
- protein serine/threonine kinase activator activity [ISO]
- protein serine/threonine/tyrosine kinase activity [TAS]
- receptor signaling protein tyrosine phosphatase activity [ISO]
Gene Ontology Cellular Component
- Golgi apparatus [IDA, TAS]
- axon [IDA]
- cell cortex [IDA]
- cytoplasm [ISO]
- cytosol [IDA, TAS]
- dendrite [IDA]
- dendrite cytoplasm [IDA]
- early endosome [TAS]
- endoplasmic reticulum [ISO]
- extracellular vesicular exosome [ISO]
- focal adhesion [TAS]
- late endosome [TAS]
- microtubule [IDA]
- mitochondrion [TAS]
- nucleus [TAS]
- perikaryon [IDA]
- perinuclear region of cytoplasm [IDA]
- plasma membrane [IDA, ISO]
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Identification and characterization of the BRI2 interactome in the brain.
BRI family proteins are ubiquitous type II transmembrane proteins but BRI2 is highly expressed in some neuronal tissues. Possible BRI2 functions include neuronal maturation and differentiation. Protein complexes appear to be important in mediating its functions. Previously described BRI2 interactors include the Alzheimer's amyloid precursor protein and protein phosphatase 1, but clearly the identification of novel interactors provides an important ... [more]
Sci Rep Feb. 23, 2018; 8(1);3548 [Pubmed: 29476059]
Throughput
- High Throughput
Curated By
- BioGRID