BAIT
ITM2B
Bri, imBRI2
integral membrane protein 2B
GO Process (2)
GO Function (2)
GO Component (8)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
OPA1
optic atrophy 1
GO Process (14)
GO Function (0)
GO Component (10)
Gene Ontology Biological Process
- aging [IEP]
- cellular senescence [ISO, ISS]
- inner mitochondrial membrane organization [ISO, ISS]
- mitochondrial fusion [ISO, ISS]
- mitochondrial genome maintenance [ISO, ISS]
- mitochondrion organization [IDA, ISO]
- negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [ISO, ISS]
- negative regulation of intrinsic apoptotic signaling pathway [ISO]
- negative regulation of release of cytochrome c from mitochondria [ISO, ISS]
- neural tube closure [ISO]
- positive regulation of dendrite development [IMP]
- positive regulation of mitochondrial fusion [IMP]
- positive regulation of neuron maturation [IMP]
- visual perception [ISO, ISS]
Gene Ontology Cellular Component
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Identification and characterization of the BRI2 interactome in the brain.
BRI family proteins are ubiquitous type II transmembrane proteins but BRI2 is highly expressed in some neuronal tissues. Possible BRI2 functions include neuronal maturation and differentiation. Protein complexes appear to be important in mediating its functions. Previously described BRI2 interactors include the Alzheimer's amyloid precursor protein and protein phosphatase 1, but clearly the identification of novel interactors provides an important ... [more]
Sci Rep Feb. 23, 2018; 8(1);3548 [Pubmed: 29476059]
Throughput
- High Throughput
Curated By
- BioGRID