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BAIT

ITM2B

Bri, imBRI2

integral membrane protein 2B

GO Process (2)

GO Function (2)

GO Component (8)

Gene Ontology Biological Process

extrinsic apoptotic signaling pathway in absence of ligand [ISO]

negative regulation of amyloid precursor protein biosynthetic process [ISO, ISS]

Gene Ontology Molecular Function

ATP binding [ISO]
beta-amyloid binding [ISO]

Gene Ontology Cellular Component

Golgi apparatus [ISO]

Golgi-associated vesicle membrane [ISO, ISS]

extracellular space [ISO, ISS]

extracellular vesicular exosome [ISO]

integral component of organelle membrane [ISO, ISS]

intracellular membrane-bounded organelle [ISO]

plasma membrane [ISO, ISS]

RGD Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl

Rattus norvegicus

PREY

SLC4A4

HHNMC, HNBC1, KNBC, NBC2, Nbc1, Nbc4, PNBC, SLC4A5

solute carrier family 4, sodium bicarbonate cotransporter, member 4

GO Process (4)

GO Function (1)

GO Component (3)

Gene Ontology Biological Process

bicarbonate transport [ISO]

regulation of pH [TAS]

sodium ion transmembrane transport [ISO, ISS, TAS]

sodium ion transport [ISO]

Gene Ontology Molecular Function

sodium:bicarbonate symporter activity [ISO, ISS, TAS]

Gene Ontology Cellular Component

basolateral plasma membrane [ISO, ISS]

extracellular vesicular exosome [ISO]

integral component of plasma membrane [TAS]

RGD Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl

Rattus norvegicus

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Identification and characterization of the BRI2 interactome in the brain.

Martins F, Marafona AM, Pereira CD, Mueller T, Loosse C, Kolbe K, da Cruz E Silva OAB, Rebelo S

BRI family proteins are ubiquitous type II transmembrane proteins but BRI2 is highly expressed in some neuronal tissues. Possible BRI2 functions include neuronal maturation and differentiation. Protein complexes appear to be important in mediating its functions. Previously described BRI2 interactors include the Alzheimer's amyloid precursor protein and protein phosphatase 1, but clearly the identification of novel interactors provides an important ... [more]

Sci Rep Feb. 23, 2018; 8(1);3548 [Pubmed: 29476059]

Throughput

High Throughput

Curated By

BioGRID