BAIT
ITM2B
Bri, imBRI2
integral membrane protein 2B
GO Process (2)
GO Function (2)
GO Component (8)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
GRIN1
GluN1, NMDAR1, NR1
glutamate receptor, ionotropic, N-methyl D-aspartate 1
GO Process (55)
GO Function (17)
GO Component (18)
Gene Ontology Biological Process
- adult locomotory behavior [ISO]
- associative learning [ISO]
- calcium ion homeostasis [ISO]
- calcium ion transmembrane transport [ISO]
- calcium ion transport [ISO]
- cation transport [ISO]
- cellular calcium ion homeostasis [ISO]
- cellular response to manganese ion [IEP]
- cerebral cortex development [ISO]
- conditioned taste aversion [ISO]
- ion transmembrane transport [IBA, ISO]
- ionotropic glutamate receptor signaling pathway [IDA, ISO]
- learning [ISO]
- learning or memory [ISO, TAS]
- long-term memory [ISO]
- male mating behavior [ISO]
- memory [ISO]
- negative regulation of neuron apoptotic process [ISO]
- neuromuscular process [ISO]
- olfactory learning [ISO]
- pons maturation [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of cell death [IDA]
- positive regulation of excitatory postsynaptic membrane potential [IDA]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- prepulse inhibition [ISO]
- propylene metabolic process [ISO]
- protein tetramerization [IDA]
- regulation of axonogenesis [ISO]
- regulation of cell communication [ISO]
- regulation of dendrite morphogenesis [ISO]
- regulation of excitatory postsynaptic membrane potential [ISO]
- regulation of ion transmembrane transport [IMP]
- regulation of long-term neuronal synaptic plasticity [ISO]
- regulation of membrane potential [ISO]
- regulation of neuron apoptotic process [ISO]
- regulation of neuronal synaptic plasticity [ISO]
- regulation of respiratory gaseous exchange [ISO]
- regulation of synapse assembly [ISO]
- regulation of synaptic plasticity [ISO]
- respiratory gaseous exchange [ISO]
- response to amine [IEP]
- response to amphetamine [ISO]
- response to calcium ion [IEP]
- response to ethanol [ISO]
- response to fungicide [IEP]
- response to morphine [ISO]
- response to organic cyclic compound [IEP]
- rhythmic process [IDA]
- sensory perception of pain [ISO]
- social behavior [ISO]
- startle response [ISO]
- suckling behavior [ISO]
- synaptic transmission, glutamatergic [IBA, ISO]
- visual learning [ISO]
Gene Ontology Molecular Function- N-methyl-D-aspartate selective glutamate receptor activity [IDA, IGI, IMP, ISO, TAS]
- calcium channel activity [ISO]
- calcium ion binding [ISO]
- calmodulin binding [ISO]
- cation channel activity [ISO]
- enzyme binding [IPI]
- extracellular-glutamate-gated ion channel activity [IBA]
- glutamate binding [IDA, ISO]
- glutamate receptor binding [IPI]
- glycine binding [IDA, ISO]
- ionotropic glutamate receptor activity [IDA, TAS]
- neurotransmitter binding [IDA]
- protein binding [IPI]
- protein dimerization activity [IDA]
- protein heterodimerization activity [IDA]
- receptor binding [IPI, ISO]
- voltage-gated cation channel activity [IMP]
- N-methyl-D-aspartate selective glutamate receptor activity [IDA, IGI, IMP, ISO, TAS]
- calcium channel activity [ISO]
- calcium ion binding [ISO]
- calmodulin binding [ISO]
- cation channel activity [ISO]
- enzyme binding [IPI]
- extracellular-glutamate-gated ion channel activity [IBA]
- glutamate binding [IDA, ISO]
- glutamate receptor binding [IPI]
- glycine binding [IDA, ISO]
- ionotropic glutamate receptor activity [IDA, TAS]
- neurotransmitter binding [IDA]
- protein binding [IPI]
- protein dimerization activity [IDA]
- protein heterodimerization activity [IDA]
- receptor binding [IPI, ISO]
- voltage-gated cation channel activity [IMP]
Gene Ontology Cellular Component
- N-methyl-D-aspartate selective glutamate receptor complex [IDA, ISO, TAS]
- cell [ISO]
- cell surface [ISO]
- cytoplasm [ISO]
- dendrite [ISO]
- dendrite membrane [IDA]
- dendritic spine [IDA, ISO]
- endoplasmic reticulum [ISO]
- excitatory synapse [IDA]
- integral component of plasma membrane [ISO]
- membrane [ISO]
- neuronal postsynaptic density [ISO]
- postsynaptic density [IDA, ISO]
- postsynaptic membrane [IBA, ISO]
- synapse [IDA, ISO]
- synaptic cleft [IDA]
- synaptic vesicle [ISO]
- terminal bouton [IDA]
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Identification and characterization of the BRI2 interactome in the brain.
BRI family proteins are ubiquitous type II transmembrane proteins but BRI2 is highly expressed in some neuronal tissues. Possible BRI2 functions include neuronal maturation and differentiation. Protein complexes appear to be important in mediating its functions. Previously described BRI2 interactors include the Alzheimer's amyloid precursor protein and protein phosphatase 1, but clearly the identification of novel interactors provides an important ... [more]
Sci Rep Feb. 23, 2018; 8(1);3548 [Pubmed: 29476059]
Throughput
- High Throughput
Curated By
- BioGRID