BAIT
ITM2B
Bri, imBRI2
integral membrane protein 2B
GO Process (2)
GO Function (2)
GO Component (8)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
KRAS
Kras2, c-Ki-ras, p21
Kirsten rat sarcoma viral oncogene
GO Process (21)
GO Function (6)
GO Component (8)
Gene Ontology Biological Process
- GTP catabolic process [ISO]
- Ras protein signal transduction [ISO]
- actin cytoskeleton organization [ISO]
- cytokine-mediated signaling pathway [IMP]
- epithelial tube branching involved in lung morphogenesis [ISO]
- negative regulation of cell differentiation [ISO]
- negative regulation of neuron apoptotic process [ISO]
- positive regulation of MAP kinase activity [IMP]
- positive regulation of NF-kappaB transcription factor activity [IMP]
- positive regulation of Rac protein signal transduction [ISO]
- positive regulation of cell proliferation [ISO, ISS]
- positive regulation of gene expression [ISO]
- positive regulation of nitric-oxide synthase activity [IMP]
- positive regulation of protein phosphorylation [ISO]
- regulation of long-term neuronal synaptic plasticity [ISO]
- regulation of synaptic transmission, GABAergic [ISO]
- response to glucocorticoid [IEP]
- response to mineralocorticoid [IEP]
- social behavior [IEP]
- striated muscle cell differentiation [ISO]
- visual learning [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Identification and characterization of the BRI2 interactome in the brain.
BRI family proteins are ubiquitous type II transmembrane proteins but BRI2 is highly expressed in some neuronal tissues. Possible BRI2 functions include neuronal maturation and differentiation. Protein complexes appear to be important in mediating its functions. Previously described BRI2 interactors include the Alzheimer's amyloid precursor protein and protein phosphatase 1, but clearly the identification of novel interactors provides an important ... [more]
Sci Rep Feb. 23, 2018; 8(1);3548 [Pubmed: 29476059]
Throughput
- High Throughput
Curated By
- BioGRID