BAIT
ITM2B
Bri, imBRI2
integral membrane protein 2B
GO Process (2)
GO Function (2)
GO Component (8)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
GNAQ
Galphaq
guanine nucleotide binding protein (G protein), q polypeptide
GO Process (24)
GO Function (8)
GO Component (8)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IDA, ISO]
- action potential [IBA, ISO]
- activation of phospholipase C activity [IMP]
- adenylate cyclase-activating G-protein coupled receptor signaling pathway [IBA, ISO]
- developmental pigmentation [ISO]
- embryonic digit morphogenesis [ISO]
- forebrain neuron development [ISO]
- glutamate receptor signaling pathway [IBA, ISO]
- heart development [ISO]
- maternal behavior [ISO]
- negative regulation of apoptotic process [IMP]
- negative regulation of potassium ion transport [IMP]
- negative regulation of protein kinase activity [ISO]
- neuron remodeling [ISO]
- phospholipase C-activating G-protein coupled receptor signaling pathway [IMP]
- phospholipase C-activating dopamine receptor signaling pathway [IBA, ISO]
- positive regulation of GTPase activity [IBA, ISO]
- positive regulation of apoptotic process [TAS]
- positive regulation of smooth muscle cell proliferation [IMP]
- post-embryonic development [ISO]
- protein stabilization [ISO]
- regulation of catenin import into nucleus [ISO]
- regulation of melanocyte differentiation [ISO]
- skeletal system development [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Identification and characterization of the BRI2 interactome in the brain.
BRI family proteins are ubiquitous type II transmembrane proteins but BRI2 is highly expressed in some neuronal tissues. Possible BRI2 functions include neuronal maturation and differentiation. Protein complexes appear to be important in mediating its functions. Previously described BRI2 interactors include the Alzheimer's amyloid precursor protein and protein phosphatase 1, but clearly the identification of novel interactors provides an important ... [more]
Sci Rep Feb. 23, 2018; 8(1);3548 [Pubmed: 29476059]
Throughput
- High Throughput
Curated By
- BioGRID