BAIT
ITM2B
Bri, imBRI2
integral membrane protein 2B
GO Process (2)
GO Function (2)
GO Component (8)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
GNAO1
Gnao, RATBPGTPC
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
GO Process (17)
GO Function (11)
GO Component (7)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IMP, ISO]
- adenylate cyclase-modulating G-protein coupled receptor signaling pathway [IBA]
- aging [IDA]
- cellular process [ISO]
- dopamine receptor signaling pathway [IBA, ISO]
- forebrain development [IEP]
- locomotory behavior [ISO]
- negative regulation of calcium ion transport [IMP]
- neuron projection development [IEP]
- positive regulation of GTPase activity [IMP]
- regulation of heart contraction [ISO]
- response to cytokine [IEP]
- response to drug [IEP]
- response to hydrogen peroxide [IEP]
- response to morphine [IEP]
- response to organic cyclic compound [IEP]
- response to organonitrogen compound [IDA]
Gene Ontology Molecular Function- G-protein beta/gamma-subunit complex binding [IBA]
- G-protein coupled serotonin receptor binding [IPI]
- GDP binding [TAS]
- GTP binding [IDA, ISO]
- GTPase activating protein binding [IPI]
- GTPase activity [IDA, ISO]
- corticotropin-releasing hormone receptor 1 binding [IPI]
- mu-type opioid receptor binding [IPI]
- protein binding [IPI]
- protein complex binding [IPI]
- signal transducer activity [IBA]
- G-protein beta/gamma-subunit complex binding [IBA]
- G-protein coupled serotonin receptor binding [IPI]
- GDP binding [TAS]
- GTP binding [IDA, ISO]
- GTPase activating protein binding [IPI]
- GTPase activity [IDA, ISO]
- corticotropin-releasing hormone receptor 1 binding [IPI]
- mu-type opioid receptor binding [IPI]
- protein binding [IPI]
- protein complex binding [IPI]
- signal transducer activity [IBA]
Gene Ontology Cellular Component
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Identification and characterization of the BRI2 interactome in the brain.
BRI family proteins are ubiquitous type II transmembrane proteins but BRI2 is highly expressed in some neuronal tissues. Possible BRI2 functions include neuronal maturation and differentiation. Protein complexes appear to be important in mediating its functions. Previously described BRI2 interactors include the Alzheimer's amyloid precursor protein and protein phosphatase 1, but clearly the identification of novel interactors provides an important ... [more]
Sci Rep Feb. 23, 2018; 8(1);3548 [Pubmed: 29476059]
Throughput
- High Throughput
Curated By
- BioGRID