BAIT
ITM2B
Bri, imBRI2
integral membrane protein 2B
GO Process (2)
GO Function (2)
GO Component (8)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
MADD
MAP-kinase activating death domain
GO Process (11)
GO Function (2)
GO Component (7)
Gene Ontology Biological Process
- activation of MAPK activity [ISO, ISS]
- execution phase of apoptosis [ISO]
- negative regulation of apoptotic signaling pathway [ISO]
- negative regulation of growth hormone secretion [IDA]
- negative regulation of pancreatic amylase secretion [IMP]
- positive regulation of Rab GTPase activity [ISO]
- regulation of Rab protein signal transduction [ISO]
- regulation of apoptotic process [ISO]
- regulation of cell cycle [ISO, ISS]
- regulation of extrinsic apoptotic signaling pathway [ISO]
- regulation of extrinsic apoptotic signaling pathway via death domain receptors [ISO, ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Identification and characterization of the BRI2 interactome in the brain.
BRI family proteins are ubiquitous type II transmembrane proteins but BRI2 is highly expressed in some neuronal tissues. Possible BRI2 functions include neuronal maturation and differentiation. Protein complexes appear to be important in mediating its functions. Previously described BRI2 interactors include the Alzheimer's amyloid precursor protein and protein phosphatase 1, but clearly the identification of novel interactors provides an important ... [more]
Sci Rep Feb. 23, 2018; 8(1);3548 [Pubmed: 29476059]
Throughput
- High Throughput
Curated By
- BioGRID