BAIT
ITM2B
Bri, imBRI2
integral membrane protein 2B
GO Process (2)
GO Function (2)
GO Component (8)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
SIRT2
sirtuin 2
GO Process (48)
GO Function (14)
GO Component (23)
Gene Ontology Biological Process
- cellular lipid catabolic process [ISO, ISS]
- cellular response to caloric restriction [ISO, ISS]
- cellular response to epinephrine stimulus [ISO, ISS]
- cellular response to hepatocyte growth factor stimulus [ISO, ISS]
- cellular response to hypoxia [ISO, ISS]
- cellular response to molecule of bacterial origin [ISO, ISS]
- cellular response to oxidative stress [ISO, ISS]
- central nervous system development [IEP]
- hepatocyte growth factor receptor signaling pathway [ISO, ISS]
- histone H3 deacetylation [ISO, ISS]
- histone H4 deacetylation [ISO, ISS]
- histone deacetylation [ISO]
- myelination in peripheral nervous system [IMP, ISO]
- negative regulation of NLRP3 inflammasome complex assembly [ISO]
- negative regulation of apoptotic process [IMP]
- negative regulation of autophagy [ISO, ISS]
- negative regulation of cell proliferation [ISO, ISS]
- negative regulation of defense response to bacterium [ISO, ISS]
- negative regulation of fat cell differentiation [ISO, ISS]
- negative regulation of oligodendrocyte differentiation [IMP]
- negative regulation of oligodendrocyte progenitor proliferation [IMP]
- negative regulation of peptidyl-threonine phosphorylation [ISO, ISS]
- negative regulation of protein catabolic process [ISO, ISS]
- negative regulation of reactive oxygen species metabolic process [ISO, ISS]
- negative regulation of striated muscle tissue development [ISO]
- negative regulation of transcription from RNA polymerase II promoter [ISO, ISS]
- negative regulation of transcription from RNA polymerase II promoter in response to hypoxia [ISO, ISS]
- negative regulation of transcription, DNA-templated [ISO]
- peptidyl-lysine deacetylation [ISO, ISS]
- phosphatidylinositol 3-kinase signaling [ISO, ISS]
- positive regulation of DNA binding [ISO, ISS]
- positive regulation of attachment of spindle microtubules to kinetochore [ISO, ISS]
- positive regulation of cell division [ISO, ISS]
- positive regulation of execution phase of apoptosis [ISO, ISS]
- positive regulation of meiosis [ISO, ISS]
- positive regulation of oocyte maturation [ISO, ISS]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [ISO, ISS]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia [ISO, ISS]
- positive regulation of transcription from RNA polymerase II promoter [ISO, ISS]
- proteasome-mediated ubiquitin-dependent protein catabolic process [ISO, ISS]
- protein deacetylation [IMP, ISO, ISS]
- protein kinase B signaling [ISO, ISS]
- regulation of cell cycle [ISO, ISS]
- regulation of fat cell differentiation [ISO]
- regulation of myelination [IMP, ISO]
- ripoptosome assembly involved in necroptotic process [ISO]
- substantia nigra development [ISO]
- tubulin deacetylation [IDA, ISO]
Gene Ontology Molecular Function- NAD+ binding [ISO]
- NAD-dependent histone deacetylase activity [ISO]
- NAD-dependent histone deacetylase activity (H4-K16 specific) [ISO, ISS]
- NAD-dependent protein deacetylase activity [IDA, ISO, ISS]
- beta-tubulin binding [ISO]
- chromatin binding [ISO, ISS]
- histone acetyltransferase binding [ISO]
- histone deacetylase activity [ISO, ISS]
- histone deacetylase binding [ISO]
- protein deacetylase activity [ISO, ISS]
- transcription factor binding [ISO]
- tubulin deacetylase activity [IDA, ISO]
- ubiquitin binding [ISO]
- zinc ion binding [ISO]
- NAD+ binding [ISO]
- NAD-dependent histone deacetylase activity [ISO]
- NAD-dependent histone deacetylase activity (H4-K16 specific) [ISO, ISS]
- NAD-dependent protein deacetylase activity [IDA, ISO, ISS]
- beta-tubulin binding [ISO]
- chromatin binding [ISO, ISS]
- histone acetyltransferase binding [ISO]
- histone deacetylase activity [ISO, ISS]
- histone deacetylase binding [ISO]
- protein deacetylase activity [ISO, ISS]
- transcription factor binding [ISO]
- tubulin deacetylase activity [IDA, ISO]
- ubiquitin binding [ISO]
- zinc ion binding [ISO]
Gene Ontology Cellular Component
- Schmidt-Lanterman incisure [IDA, ISO, ISS]
- centriole [ISO, ISS]
- centrosome [ISO, ISS]
- chromosome [ISO, ISS]
- cytoplasm [IDA, ISO, ISS]
- cytosol [ISO, ISS]
- glial cell projection [IDA]
- juxtaparanode region of axon [IDA]
- lateral loop [IDA]
- meiotic spindle [ISO, ISS]
- microtubule [ISO]
- midbody [ISO, ISS]
- mitotic spindle [ISO, ISS]
- myelin sheath [IDA, ISO, ISS]
- myelin sheath abaxonal region [IDA]
- nuclear heterochromatin [IDA]
- nucleus [IDA, ISO, ISS]
- paranodal junction [IDA, ISO, ISS]
- paranode region of axon [IDA]
- perikaryon [IDA, ISO, ISS]
- perinuclear region of cytoplasm [ISO, ISS]
- spindle [ISO, ISS]
- terminal loop [IDA]
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Identification and characterization of the BRI2 interactome in the brain.
BRI family proteins are ubiquitous type II transmembrane proteins but BRI2 is highly expressed in some neuronal tissues. Possible BRI2 functions include neuronal maturation and differentiation. Protein complexes appear to be important in mediating its functions. Previously described BRI2 interactors include the Alzheimer's amyloid precursor protein and protein phosphatase 1, but clearly the identification of novel interactors provides an important ... [more]
Sci Rep Feb. 23, 2018; 8(1);3548 [Pubmed: 29476059]
Throughput
- High Throughput
Curated By
- BioGRID