BAIT
ITM2B
Bri, imBRI2
integral membrane protein 2B
GO Process (2)
GO Function (2)
GO Component (8)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
ATP2B4
PMCA4
ATPase, Ca++ transporting, plasma membrane 4
GO Process (21)
GO Function (8)
GO Component (9)
Gene Ontology Biological Process
- calcium ion export [IMP]
- calcium ion transmembrane transport [IMP, ISO]
- calcium ion transport [IDA]
- cellular calcium ion homeostasis [ISO, TAS]
- cellular response to epinephrine stimulus [ISO]
- hippocampus development [IEP]
- negative regulation of adrenergic receptor signaling pathway involved in heart process [ISO]
- negative regulation of arginine catabolic process [ISO]
- negative regulation of calcineurin-NFAT signaling cascade [IMP, ISO]
- negative regulation of cardiac muscle hypertrophy in response to stress [ISO]
- negative regulation of citrulline biosynthetic process [ISO]
- negative regulation of nitric oxide biosynthetic process [ISO]
- negative regulation of nitric oxide mediated signal transduction [ISO]
- negative regulation of nitric-oxide synthase activity [ISO]
- negative regulation of the force of heart contraction [ISO]
- neural retina development [IEP]
- positive regulation of cAMP-dependent protein kinase activity [ISO]
- positive regulation of peptidyl-serine phosphorylation [ISO]
- regulation of transcription from RNA polymerase II promoter [ISO]
- response to hydrostatic pressure [ISO]
- spermatogenesis [IEP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Identification and characterization of the BRI2 interactome in the brain.
BRI family proteins are ubiquitous type II transmembrane proteins but BRI2 is highly expressed in some neuronal tissues. Possible BRI2 functions include neuronal maturation and differentiation. Protein complexes appear to be important in mediating its functions. Previously described BRI2 interactors include the Alzheimer's amyloid precursor protein and protein phosphatase 1, but clearly the identification of novel interactors provides an important ... [more]
Sci Rep Feb. 23, 2018; 8(1);3548 [Pubmed: 29476059]
Throughput
- High Throughput
Curated By
- BioGRID