BAIT
ITM2B
Bri, imBRI2
integral membrane protein 2B
GO Process (2)
GO Function (2)
GO Component (8)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
PARK7
CAP1, DJ-1, Dj1, SP22
parkinson protein 7
GO Process (67)
GO Function (26)
GO Component (10)
Gene Ontology Biological Process
- adult locomotory behavior [ISO]
- cellular response to glyoxal [ISO, ISS]
- cellular response to hydrogen peroxide [ISO, ISS]
- cellular response to oxidative stress [ISO, ISS]
- cellular response to reactive oxygen species [ISO]
- dopamine uptake involved in synaptic transmission [ISO]
- fertilization [TAS]
- glycolate biosynthetic process [ISO, ISS]
- glyoxal catabolic process [ISO, ISS]
- hydrogen peroxide metabolic process [ISO, ISS]
- lactate biosynthetic process [ISO, ISS]
- membrane depolarization [ISO]
- membrane hyperpolarization [ISO]
- methylglyoxal catabolic process to D-lactate [ISO, ISS]
- mitochondrion organization [ISO, ISS]
- negative regulation of TRAIL-activated apoptotic signaling pathway [ISO, ISS]
- negative regulation of apoptotic process [ISO]
- negative regulation of cell death [ISO, ISS]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway [ISO, ISS]
- negative regulation of extrinsic apoptotic signaling pathway [ISO, ISS]
- negative regulation of gene expression [ISO]
- negative regulation of hydrogen peroxide-induced cell death [ISO]
- negative regulation of hydrogen peroxide-induced neuron death [ISO]
- negative regulation of neuron apoptotic process [ISO, ISS]
- negative regulation of neuron death [ISO]
- negative regulation of oxidative stress-induced cell death [ISO]
- negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [ISO, ISS]
- negative regulation of proteasomal ubiquitin-dependent protein catabolic process [ISO]
- negative regulation of protein K48-linked deubiquitination [ISO, ISS]
- negative regulation of protein acetylation [ISO, ISS]
- negative regulation of protein binding [ISO, ISS]
- negative regulation of protein export from nucleus [ISO, ISS]
- negative regulation of protein kinase activity [ISO, ISS]
- negative regulation of protein phosphorylation [ISO, ISS]
- negative regulation of protein sumoylation [ISO, ISS]
- negative regulation of protein ubiquitination [ISO, ISS]
- negative regulation of ubiquitin-protein transferase activity [ISO]
- negative regulation of ubiquitin-specific protease activity [ISO, ISS]
- oxidation-reduction process [ISO]
- positive regulation of L-dopa biosynthetic process [ISO, ISS]
- positive regulation of L-dopa decarboxylase activity [ISO, ISS]
- positive regulation of androgen receptor activity [ISO, ISS]
- positive regulation of dopamine biosynthetic process [ISO, ISS]
- positive regulation of interleukin-8 production [ISO, ISS]
- positive regulation of mitochondrial electron transport, NADH to ubiquinone [ISO, ISS]
- positive regulation of oxidative phosphorylation uncoupler activity [ISO, ISS]
- positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [ISO]
- positive regulation of peptidyl-serine phosphorylation [ISO]
- positive regulation of protein homodimerization activity [ISO, ISS]
- positive regulation of protein localization to nucleus [ISO, ISS]
- positive regulation of pyrroline-5-carboxylate reductase activity [ISO, ISS]
- positive regulation of reactive oxygen species biosynthetic process [ISO]
- positive regulation of sequence-specific DNA binding transcription factor activity [ISO]
- positive regulation of superoxide dismutase activity [ISO, ISS]
- positive regulation of transcription from RNA polymerase II promoter [ISO, ISS]
- positive regulation of transcription regulatory region DNA binding [ISO]
- positive regulation of tyrosine 3-monooxygenase activity [ISO, ISS]
- protein stabilization [ISO, ISS]
- regulation of TRAIL receptor biosynthetic process [ISO]
- regulation of androgen receptor signaling pathway [ISO, ISS]
- regulation of inflammatory response [ISO, ISS]
- regulation of mitochondrial membrane potential [ISO, ISS]
- regulation of neuron apoptotic process [ISO, ISS]
- response to drug [IEP]
- response to hydrogen peroxide [ISO]
- response to oxidative stress [IMP]
- synaptic transmission, dopaminergic [ISO]
Gene Ontology Molecular Function- L-dopa decarboxylase activator activity [ISO, ISS]
- androgen receptor binding [ISO, ISS]
- cupric ion binding [ISO, ISS]
- cuprous ion binding [ISO, ISS]
- cytokine binding [ISO, ISS]
- double-stranded DNA binding [ISO]
- enzyme binding [ISO]
- glyoxalase (glycolic acid-forming) activity [ISO, ISS]
- glyoxalase III activity [ISO, ISS]
- identical protein binding [ISO]
- mRNA binding [ISO, ISS]
- oxidoreductase activity, acting on peroxide as acceptor [ISO]
- peptidase activity [ISO, ISS]
- peroxiredoxin activity [ISO]
- protein homodimerization activity [ISO, ISS]
- receptor binding [ISO, ISS]
- repressing transcription factor binding [ISO, ISS]
- scaffold protein binding [ISO, ISS]
- single-stranded DNA binding [ISO]
- small protein activating enzyme binding [ISO, ISS]
- small protein conjugating enzyme binding [ISO, ISS]
- superoxide dismutase copper chaperone activity [ISO, ISS]
- transcription coactivator activity [ISO, ISS]
- transcription factor binding [ISO, ISS]
- tyrosine 3-monooxygenase activator activity [ISO, ISS]
- ubiquitin-specific protease binding [ISO, ISS]
- L-dopa decarboxylase activator activity [ISO, ISS]
- androgen receptor binding [ISO, ISS]
- cupric ion binding [ISO, ISS]
- cuprous ion binding [ISO, ISS]
- cytokine binding [ISO, ISS]
- double-stranded DNA binding [ISO]
- enzyme binding [ISO]
- glyoxalase (glycolic acid-forming) activity [ISO, ISS]
- glyoxalase III activity [ISO, ISS]
- identical protein binding [ISO]
- mRNA binding [ISO, ISS]
- oxidoreductase activity, acting on peroxide as acceptor [ISO]
- peptidase activity [ISO, ISS]
- peroxiredoxin activity [ISO]
- protein homodimerization activity [ISO, ISS]
- receptor binding [ISO, ISS]
- repressing transcription factor binding [ISO, ISS]
- scaffold protein binding [ISO, ISS]
- single-stranded DNA binding [ISO]
- small protein activating enzyme binding [ISO, ISS]
- small protein conjugating enzyme binding [ISO, ISS]
- superoxide dismutase copper chaperone activity [ISO, ISS]
- transcription coactivator activity [ISO, ISS]
- transcription factor binding [ISO, ISS]
- tyrosine 3-monooxygenase activator activity [ISO, ISS]
- ubiquitin-specific protease binding [ISO, ISS]
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Identification and characterization of the BRI2 interactome in the brain.
BRI family proteins are ubiquitous type II transmembrane proteins but BRI2 is highly expressed in some neuronal tissues. Possible BRI2 functions include neuronal maturation and differentiation. Protein complexes appear to be important in mediating its functions. Previously described BRI2 interactors include the Alzheimer's amyloid precursor protein and protein phosphatase 1, but clearly the identification of novel interactors provides an important ... [more]
Sci Rep Feb. 23, 2018; 8(1);3548 [Pubmed: 29476059]
Throughput
- High Throughput
Curated By
- BioGRID