BAIT
ITM2B
Bri, imBRI2
integral membrane protein 2B
GO Process (2)
GO Function (2)
GO Component (8)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
RAPGEF2
PDZ-GEF1, RA-GEF-1, nRap GEP
Rap guanine nucleotide exchange factor (GEF) 2
GO Process (32)
GO Function (10)
GO Component (11)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [ISO, ISS]
- Rap protein signal transduction [ISO, ISS]
- adenylate cyclase-activating adrenergic receptor signaling pathway [ISO, ISS]
- blood vessel development [ISO, ISS]
- brain-derived neurotrophic factor receptor signaling pathway [IMP]
- cAMP-mediated signaling [ISO, ISS]
- cellular response to cAMP [ISO, ISS]
- cellular response to cGMP [ISO, ISS]
- cellular response to nerve growth factor stimulus [IDA]
- establishment of endothelial barrier [ISO, ISS]
- forebrain neuron development [ISO, ISS]
- negative regulation of cell proliferation [ISO, ISS]
- negative regulation of dendrite morphogenesis [ISO, ISS]
- negative regulation of melanin biosynthetic process [ISO, ISS]
- nerve growth factor signaling pathway [IDA]
- neuron migration [ISO, ISS]
- neuron projection development [ISO, ISS]
- neuropeptide signaling pathway [ISO, ISS]
- positive regulation of ERK1 and ERK2 cascade [IMP, ISO, ISS]
- positive regulation of Rap GTPase activity [IDA, IMP, ISO]
- positive regulation of Ras GTPase activity [ISO, ISS]
- positive regulation of cAMP-dependent protein kinase activity [ISO, ISS]
- positive regulation of cAMP-mediated signaling [ISO, ISS]
- positive regulation of dendritic cell apoptotic process [ISO, ISS]
- positive regulation of neuron migration [ISO, ISS]
- positive regulation of neuron projection development [IMP]
- positive regulation of protein binding [ISO, ISS]
- positive regulation of protein kinase activity [IMP, ISO, ISS]
- positive regulation of vasculogenesis [ISO, ISS]
- regulation of cell junction assembly [ISO, ISS]
- regulation of synaptic plasticity [IDA]
- ventricular system development [ISO, ISS]
Gene Ontology Molecular Function- PDZ domain binding [ISO, ISS]
- Rap GTPase activator activity [ISO]
- Rap guanyl-nucleotide exchange factor activity [IMP, ISO, ISS]
- Ras guanyl-nucleotide exchange factor activity [ISO, ISS]
- WW domain binding [ISO, ISS]
- beta-1 adrenergic receptor binding [ISO, ISS]
- cAMP binding [ISO, ISS]
- cGMP binding [ISO]
- protein binding [IPI]
- protein kinase binding [IPI]
- PDZ domain binding [ISO, ISS]
- Rap GTPase activator activity [ISO]
- Rap guanyl-nucleotide exchange factor activity [IMP, ISO, ISS]
- Ras guanyl-nucleotide exchange factor activity [ISO, ISS]
- WW domain binding [ISO, ISS]
- beta-1 adrenergic receptor binding [ISO, ISS]
- cAMP binding [ISO, ISS]
- cGMP binding [ISO]
- protein binding [IPI]
- protein kinase binding [IPI]
Gene Ontology Cellular Component
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Identification and characterization of the BRI2 interactome in the brain.
BRI family proteins are ubiquitous type II transmembrane proteins but BRI2 is highly expressed in some neuronal tissues. Possible BRI2 functions include neuronal maturation and differentiation. Protein complexes appear to be important in mediating its functions. Previously described BRI2 interactors include the Alzheimer's amyloid precursor protein and protein phosphatase 1, but clearly the identification of novel interactors provides an important ... [more]
Sci Rep Feb. 23, 2018; 8(1);3548 [Pubmed: 29476059]
Throughput
- High Throughput
Curated By
- BioGRID