BAIT
ITM2B
Bri, imBRI2
integral membrane protein 2B
GO Process (2)
GO Function (2)
GO Component (8)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
RAC1
ras-related C3 botulinum toxin substrate 1
GO Process (52)
GO Function (10)
GO Component (16)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [ISO]
- GTP catabolic process [IDA, ISO]
- Rac protein signal transduction [TAS]
- Wnt signaling pathway, planar cell polarity pathway [ISO]
- actin cytoskeleton organization [IDA, ISO]
- actin filament organization [IMP]
- actin filament polymerization [ISO]
- anatomical structure arrangement [ISO]
- auditory receptor cell morphogenesis [ISO]
- axon guidance [ISO]
- bone resorption [IDA]
- cell adhesion [ISO]
- cell migration [ISO]
- cell motility [ISO, ISS]
- cell proliferation [IMP]
- cell-cell junction organization [ISO]
- cellular component movement [IMP]
- cerebral cortex radially oriented cell migration [ISO]
- chemotaxis [IMP]
- cochlea morphogenesis [ISO]
- cytoskeleton organization [ISO]
- dendrite development [ISO]
- dendrite morphogenesis [ISO]
- dopaminergic neuron differentiation [ISO]
- embryonic olfactory bulb interneuron precursor migration [ISO]
- endocytosis [ISO]
- engulfment of apoptotic cell [ISO]
- epithelial cell morphogenesis [ISO]
- hyperosmotic response [ISO]
- lamellipodium assembly [ISO]
- localization within membrane [ISO]
- mast cell chemotaxis [IMP]
- negative regulation of interleukin-23 production [ISO]
- phagocytosis, engulfment [ISO]
- positive regulation of DNA replication [IMP]
- positive regulation of actin filament polymerization [ISO]
- positive regulation of cell-substrate adhesion [ISO]
- positive regulation of focal adhesion assembly [ISO]
- positive regulation of lamellipodium assembly [ISO]
- positive regulation of neutrophil chemotaxis [ISO]
- positive regulation of phosphatidylinositol 3-kinase activity [ISO]
- positive regulation of protein phosphorylation [ISO, ISS]
- positive regulation of stress fiber assembly [ISO]
- positive regulation of substrate adhesion-dependent cell spreading [ISO]
- protein localization to plasma membrane [ISO]
- regulation of cell migration [ISO, ISS]
- regulation of respiratory burst [ISO]
- ruffle assembly [ISO]
- ruffle organization [ISO]
- semaphorin-plexin signaling pathway [IMP]
- small GTPase mediated signal transduction [ISO]
- substrate adhesion-dependent cell spreading [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi membrane [IDA]
- actin filament [ISO]
- cell projection [ISO]
- cytoplasm [IDA, ISO]
- cytoplasmic membrane-bounded vesicle [ISO]
- cytoplasmic ribonucleoprotein granule [ISO]
- cytoplasmic vesicle [IDA]
- cytosol [IDA]
- extracellular vesicular exosome [ISO]
- extrinsic component of plasma membrane [ISO]
- focal adhesion [ISO]
- lamellipodium [ISO]
- membrane [IDA, ISO]
- phagocytic cup [ISO]
- ruffle membrane [ISO]
- trans-Golgi network [ISO]
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Identification and characterization of the BRI2 interactome in the brain.
BRI family proteins are ubiquitous type II transmembrane proteins but BRI2 is highly expressed in some neuronal tissues. Possible BRI2 functions include neuronal maturation and differentiation. Protein complexes appear to be important in mediating its functions. Previously described BRI2 interactors include the Alzheimer's amyloid precursor protein and protein phosphatase 1, but clearly the identification of novel interactors provides an important ... [more]
Sci Rep Feb. 23, 2018; 8(1);3548 [Pubmed: 29476059]
Throughput
- High Throughput
Curated By
- BioGRID