BAIT
ITM2B
Bri, imBRI2
integral membrane protein 2B
GO Process (2)
GO Function (2)
GO Component (8)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
RAB5A
RAB5A, member RAS oncogene family
GO Process (14)
GO Function (5)
GO Component (24)
Gene Ontology Biological Process
- GTP catabolic process [ISO]
- early endosome to late endosome transport [ISO]
- endocytosis [IMP, ISO]
- endosome organization [IMP]
- positive regulation of exocytosis [ISO]
- positive regulation of smooth muscle cell migration [IMP]
- positive regulation of smooth muscle cell proliferation [IMP]
- receptor internalization involved in canonical Wnt signaling pathway [ISO]
- regulation of endosome size [ISO]
- regulation of filopodium assembly [ISO]
- regulation of long-term neuronal synaptic plasticity [IMP]
- regulation of synaptic vesicle exocytosis [ISO, ISS]
- synaptic vesicle recycling [ISO]
- vesicle-mediated transport [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- actin cytoskeleton [ISO]
- axon [IDA]
- axon terminus [IDA]
- cytoplasm [IDA, ISO]
- cytoplasmic side of early endosome membrane [ISO]
- cytosol [ISO]
- dendrite [IDA]
- early endosome [IDA, ISO]
- endocytic vesicle [ISO]
- endosome [IDA, ISO]
- extracellular vesicular exosome [ISO]
- membrane raft [ISO]
- neuron projection [IDA]
- neuronal cell body [IDA]
- perinuclear region of cytoplasm [IDA]
- phagocytic vesicle [ISO]
- plasma membrane [IDA, ISO]
- protein complex [IDA]
- recycling endosome [IDA]
- ruffle [ISO]
- somatodendritic compartment [IDA, ISO]
- synaptic vesicle [IDA]
- terminal bouton [IDA, ISO, ISS]
- zymogen granule membrane [IDA]
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Identification and characterization of the BRI2 interactome in the brain.
BRI family proteins are ubiquitous type II transmembrane proteins but BRI2 is highly expressed in some neuronal tissues. Possible BRI2 functions include neuronal maturation and differentiation. Protein complexes appear to be important in mediating its functions. Previously described BRI2 interactors include the Alzheimer's amyloid precursor protein and protein phosphatase 1, but clearly the identification of novel interactors provides an important ... [more]
Sci Rep Feb. 23, 2018; 8(1);3548 [Pubmed: 29476059]
Throughput
- High Throughput
Curated By
- BioGRID