BAIT
ITM2B
Bri, imBRI2
integral membrane protein 2B
GO Process (2)
GO Function (2)
GO Component (8)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
RAB7A
Rab7
RAB7A, member RAS oncogene family
GO Process (14)
GO Function (5)
GO Component (13)
Gene Ontology Biological Process
- GTP catabolic process [IBA, ISO]
- Rab protein signal transduction [IBA]
- bone resorption [IMP]
- early endosome to late endosome transport [ISO, ISS]
- endosome to lysosome transport [IBA, ISO]
- epidermal growth factor catabolic process [ISO]
- intracellular protein transport [IBA]
- phagosome acidification [ISO, ISS]
- phagosome-lysosome fusion [IBA, ISO, ISS]
- positive regulation of exosomal secretion [ISO]
- protein targeting to lysosome [ISO]
- protein to membrane docking [ISO]
- regulation of autophagic vacuole assembly [ISO]
- retrograde transport, endosome to Golgi [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [ISO]
- alveolar lamellar body [IDA]
- cytoplasm [ISO]
- cytoplasmic vesicle [IDA]
- extracellular vesicular exosome [ISO]
- intracellular membrane-bounded organelle [ISO]
- late endosome [IDA, ISO, TAS]
- lysosome [IBA, ISO]
- phagocytic vesicle [IBA, ISO, ISS]
- pre-autophagosomal structure membrane [ISO]
- retromer complex [ISO]
- terminal bouton [IDA]
- vacuolar membrane [IBA]
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Identification and characterization of the BRI2 interactome in the brain.
BRI family proteins are ubiquitous type II transmembrane proteins but BRI2 is highly expressed in some neuronal tissues. Possible BRI2 functions include neuronal maturation and differentiation. Protein complexes appear to be important in mediating its functions. Previously described BRI2 interactors include the Alzheimer's amyloid precursor protein and protein phosphatase 1, but clearly the identification of novel interactors provides an important ... [more]
Sci Rep Feb. 23, 2018; 8(1);3548 [Pubmed: 29476059]
Throughput
- High Throughput
Curated By
- BioGRID