BAIT
ITM2B
Bri, imBRI2
integral membrane protein 2B
GO Process (2)
GO Function (2)
GO Component (8)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
RTN4
NI-250, Nogo, Nogo-A, Vp20, r, rat N, rat NogoA
reticulon 4
GO Process (23)
GO Function (3)
GO Component (14)
Gene Ontology Biological Process
- aging [IEP]
- angiogenesis [ISO]
- axonal fasciculation [IDA, ISO]
- cardiac epithelial to mesenchymal transition [ISO]
- cerebral cortex radial glia guided migration [ISO, ISS]
- endoplasmic reticulum tubular network organization [ISO]
- negative regulation of axon extension [IDA, ISO, ISS]
- negative regulation of axonogenesis [IDA, IMP]
- negative regulation of cell growth [ISO]
- negative regulation of neuron differentiation [IDA]
- negative regulation of neuron projection development [IDA]
- negative regulation of neuron projection regeneration [IMP]
- nervous system development [ISO]
- olfactory nerve development [IEP]
- oligodendrocyte differentiation [IEP]
- positive regulation of dopamine secretion [IMP]
- positive regulation of glial cell differentiation [IDA]
- regulation of axon regeneration [IDA]
- regulation of branching morphogenesis of a nerve [IDA, ISO]
- regulation of cell migration [ISO]
- regulation of nervous system development [ISO]
- regulation of sensory perception of pain [IDA]
- response to activity [IEP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- cell projection [ISO]
- cytoplasm [IDA]
- endoplasmic reticulum [IDA, ISO]
- extracellular vesicular exosome [ISO]
- integral component of endoplasmic reticulum membrane [IDA, ISO]
- integral component of membrane [TAS]
- intracellular [IDA, ISO]
- myelin sheath [IDA]
- neuron projection [IDA]
- neuronal cell body [IDA, ISO]
- neuronal postsynaptic density [ISO]
- nuclear envelope [ISO, ISS]
- plasma membrane [IDA]
- protein complex [IDA]
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Identification and characterization of the BRI2 interactome in the brain.
BRI family proteins are ubiquitous type II transmembrane proteins but BRI2 is highly expressed in some neuronal tissues. Possible BRI2 functions include neuronal maturation and differentiation. Protein complexes appear to be important in mediating its functions. Previously described BRI2 interactors include the Alzheimer's amyloid precursor protein and protein phosphatase 1, but clearly the identification of novel interactors provides an important ... [more]
Sci Rep Feb. 23, 2018; 8(1);3548 [Pubmed: 29476059]
Throughput
- High Throughput
Curated By
- BioGRID