BAIT
ITM2B
Bri, imBRI2
integral membrane protein 2B
GO Process (2)
GO Function (2)
GO Component (8)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
ATP2A1
Serca1
ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
GO Process (20)
GO Function (6)
GO Component (9)
Gene Ontology Biological Process
- ATP catabolic process [ISS]
- apoptotic mitochondrial changes [ISO]
- calcium ion import [ISO]
- calcium ion transmembrane transport [IDA, IMP, ISO, ISS]
- calcium ion transport [IDA, ISO, ISS]
- carbohydrate derivative transport [IDA]
- intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [ISO]
- maintenance of mitochondrion location [ISO]
- negative regulation of endoplasmic reticulum calcium ion concentration [ISO]
- negative regulation of striated muscle contraction [ISO, ISS]
- nucleotide transmembrane transport [IDA]
- positive regulation of endoplasmic reticulum calcium ion concentration [ISO]
- positive regulation of fast-twitch skeletal muscle fiber contraction [ISO, ISS]
- positive regulation of mitochondrial calcium ion concentration [ISO]
- regulation of muscle contraction [TAS]
- regulation of striated muscle contraction [ISO, ISS]
- relaxation of skeletal muscle [ISO]
- response to endoplasmic reticulum stress [ISO]
- response to peptide hormone [IDA]
- sarcoplasmic reticulum calcium ion transport [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- H zone [ISO, ISS]
- I band [ISO, ISS]
- endoplasmic reticulum [ISS]
- endoplasmic reticulum membrane [ISO, ISS]
- endoplasmic reticulum-Golgi intermediate compartment [ISS]
- intracellular membrane-bounded organelle [IDA]
- membrane [ISS]
- perinuclear region of cytoplasm [ISS]
- sarcoplasmic reticulum [IDA, ISO, ISS, TAS]
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Identification and characterization of the BRI2 interactome in the brain.
BRI family proteins are ubiquitous type II transmembrane proteins but BRI2 is highly expressed in some neuronal tissues. Possible BRI2 functions include neuronal maturation and differentiation. Protein complexes appear to be important in mediating its functions. Previously described BRI2 interactors include the Alzheimer's amyloid precursor protein and protein phosphatase 1, but clearly the identification of novel interactors provides an important ... [more]
Sci Rep Feb. 23, 2018; 8(1);3548 [Pubmed: 29476059]
Throughput
- High Throughput
Curated By
- BioGRID