BAIT
ITM2B
Bri, imBRI2
integral membrane protein 2B
GO Process (2)
GO Function (2)
GO Component (8)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
ATP2A2
Serca2, SercaII
ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
GO Process (20)
GO Function (9)
GO Component (13)
Gene Ontology Biological Process
- ATP catabolic process [IDA, ISO]
- ER-nucleus signaling pathway [ISO]
- calcium ion import into sarcoplasmic reticulum [IDA]
- calcium ion transmembrane transport [IDA, ISO]
- calcium ion transport [IDA]
- calcium ion transport from cytosol to endoplasmic reticulum [ISO]
- cellular calcium ion homeostasis [ISO]
- endoplasmic reticulum calcium ion homeostasis [ISO]
- negative regulation of heart contraction [ISO]
- positive regulation of endoplasmic reticulum calcium ion concentration [ISO]
- regulation of calcium ion-dependent exocytosis of neurotransmitter [ISO]
- regulation of cardiac muscle cell action potential involved in regulation of contraction [IDA]
- regulation of cardiac muscle cell membrane potential [IDA]
- regulation of cardiac muscle contraction by calcium ion signaling [IDA, ISO]
- regulation of muscle contraction [TAS]
- regulation of the force of heart contraction [ISO]
- relaxation of cardiac muscle [IDA, ISO]
- response to peptide hormone [IDA]
- sarcoplasmic reticulum calcium ion transport [IDA]
- transition between fast and slow fiber [ISO]
Gene Ontology Molecular Function- ATP binding [IDA]
- S100 protein binding [ISO]
- calcium ion binding [IDA, ISO]
- calcium-transporting ATPase activity [IDA, ISO]
- calcium-transporting ATPase activity involved in regulation of cardiac muscle cell membrane potential [IDA]
- enzyme binding [ISO]
- lutropin-choriogonadotropic hormone receptor binding [IPI]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- ATP binding [IDA]
- S100 protein binding [ISO]
- calcium ion binding [IDA, ISO]
- calcium-transporting ATPase activity [IDA, ISO]
- calcium-transporting ATPase activity involved in regulation of cardiac muscle cell membrane potential [IDA]
- enzyme binding [ISO]
- lutropin-choriogonadotropic hormone receptor binding [IPI]
- protein C-terminus binding [ISO]
- protein binding [IPI]
Gene Ontology Cellular Component
- calcium ion-transporting ATPase complex [ISO]
- cell [ISO]
- endoplasmic reticulum [ISO]
- endoplasmic reticulum membrane [ISO]
- extrinsic component of cytoplasmic side of plasma membrane [IDA]
- intercalated disc [ISO]
- longitudinal sarcoplasmic reticulum [ISO]
- membrane [ISO]
- perinuclear region of cytoplasm [IDA]
- protein complex [IDA]
- sarcoplasmic reticulum [IDA, ISO, TAS]
- sarcoplasmic reticulum membrane [IC]
- vesicle membrane [IDA]
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Identification and characterization of the BRI2 interactome in the brain.
BRI family proteins are ubiquitous type II transmembrane proteins but BRI2 is highly expressed in some neuronal tissues. Possible BRI2 functions include neuronal maturation and differentiation. Protein complexes appear to be important in mediating its functions. Previously described BRI2 interactors include the Alzheimer's amyloid precursor protein and protein phosphatase 1, but clearly the identification of novel interactors provides an important ... [more]
Sci Rep Feb. 23, 2018; 8(1);3548 [Pubmed: 29476059]
Throughput
- High Throughput
Curated By
- BioGRID