BAIT
ITM2B
Bri, imBRI2
integral membrane protein 2B
GO Process (2)
GO Function (2)
GO Component (8)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
PPP3CA
Calna1
protein phosphatase 3, catalytic subunit, alpha isozyme
GO Process (21)
GO Function (10)
GO Component (9)
Gene Ontology Biological Process
- G1/S transition of mitotic cell cycle [ISO]
- calcineurin-NFAT signaling cascade [ISO]
- calcium ion transport [ISO]
- calcium-mediated signaling [ISO]
- cellular response to drug [ISO]
- cellular response to glucose stimulus [IMP]
- dephosphorylation [ISO]
- multicellular organismal response to stress [ISO]
- negative regulation of calcium ion-dependent exocytosis [IC]
- negative regulation of insulin secretion [IMP]
- positive regulation of NFAT protein import into nucleus [ISO]
- positive regulation of cardiac muscle hypertrophy in response to stress [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- protein dephosphorylation [IDA, ISO]
- protein import into nucleus [ISO]
- regulation of excitatory postsynaptic membrane potential [ISO]
- regulation of synaptic transmission [ISO]
- response to amphetamine [IEP]
- response to calcium ion [ISO, ISS]
- skeletal muscle fiber development [ISO]
- transition between fast and slow fiber [ISO]
Gene Ontology Molecular Function- calcium-dependent protein serine/threonine phosphatase activity [IDA]
- calmodulin binding [IDA, ISO]
- calmodulin-dependent protein phosphatase activity [ISO, ISS]
- drug binding [ISO]
- enzyme binding [ISO]
- phosphoprotein phosphatase activity [IDA, ISO]
- protein binding [IPI]
- protein dimerization activity [ISO]
- protein heterodimerization activity [IDA]
- protein serine/threonine phosphatase activity [IDA, TAS]
- calcium-dependent protein serine/threonine phosphatase activity [IDA]
- calmodulin binding [IDA, ISO]
- calmodulin-dependent protein phosphatase activity [ISO, ISS]
- drug binding [ISO]
- enzyme binding [ISO]
- phosphoprotein phosphatase activity [IDA, ISO]
- protein binding [IPI]
- protein dimerization activity [ISO]
- protein heterodimerization activity [IDA]
- protein serine/threonine phosphatase activity [IDA, TAS]
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Identification and characterization of the BRI2 interactome in the brain.
BRI family proteins are ubiquitous type II transmembrane proteins but BRI2 is highly expressed in some neuronal tissues. Possible BRI2 functions include neuronal maturation and differentiation. Protein complexes appear to be important in mediating its functions. Previously described BRI2 interactors include the Alzheimer's amyloid precursor protein and protein phosphatase 1, but clearly the identification of novel interactors provides an important ... [more]
Sci Rep Feb. 23, 2018; 8(1);3548 [Pubmed: 29476059]
Throughput
- High Throughput
Curated By
- BioGRID