BAIT
ITM2B
Bri, imBRI2
integral membrane protein 2B
GO Process (2)
GO Function (2)
GO Component (8)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
SHANK1
Shank1a, Spank1, Sstrip
SH3 and multiple ankyrin repeat domains 1
GO Process (19)
GO Function (11)
GO Component (12)
Gene Ontology Biological Process
- adult behavior [ISO]
- associative learning [ISO, ISS]
- cytoskeletal anchoring at plasma membrane [NAS]
- dendritic spine morphogenesis [ISO, ISS]
- determination of affect [ISO]
- habituation [ISO, ISS]
- long-term memory [ISO, ISS]
- negative regulation of actin filament bundle assembly [ISO, ISS]
- neuromuscular process controlling balance [ISO, ISS]
- olfactory behavior [ISO, ISS]
- positive regulation of dendritic spine development [IDA]
- positive regulation of excitatory postsynaptic membrane potential [ISO, ISS]
- protein complex assembly [IDA]
- protein localization to synapse [ISO, ISS]
- regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [ISO, ISS]
- righting reflex [ISO, ISS]
- social behavior [ISO]
- synapse maturation [IDA]
- vocalization behavior [ISO]
Gene Ontology Molecular Function- GKAP/Homer scaffold activity [IDA, ISO]
- SH3 domain binding [IPI]
- ankyrin repeat binding [IPI]
- identical protein binding [IPI]
- ionotropic glutamate receptor binding [IPI, ISO]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- protein complex binding [IPI]
- receptor signaling complex scaffold activity [IDA]
- scaffold protein binding [IPI]
- somatostatin receptor binding [IPI]
- GKAP/Homer scaffold activity [IDA, ISO]
- SH3 domain binding [IPI]
- ankyrin repeat binding [IPI]
- identical protein binding [IPI]
- ionotropic glutamate receptor binding [IPI, ISO]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- protein complex binding [IPI]
- receptor signaling complex scaffold activity [IDA]
- scaffold protein binding [IPI]
- somatostatin receptor binding [IPI]
Gene Ontology Cellular Component
- N-methyl-D-aspartate selective glutamate receptor complex [IDA]
- dendrite [ISO, NAS]
- dendritic spine [IDA, ISO]
- excitatory synapse [ISO, ISS]
- intracellular [NAS]
- ionotropic glutamate receptor complex [ISO, ISS]
- membrane [ISO]
- neuron projection [ISO, ISS]
- neuronal postsynaptic density [ISO, ISS]
- plasma membrane [ISO, ISS]
- postsynaptic membrane [IDA, ISO]
- synapse [IDA]
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Identification and characterization of the BRI2 interactome in the brain.
BRI family proteins are ubiquitous type II transmembrane proteins but BRI2 is highly expressed in some neuronal tissues. Possible BRI2 functions include neuronal maturation and differentiation. Protein complexes appear to be important in mediating its functions. Previously described BRI2 interactors include the Alzheimer's amyloid precursor protein and protein phosphatase 1, but clearly the identification of novel interactors provides an important ... [more]
Sci Rep Feb. 23, 2018; 8(1);3548 [Pubmed: 29476059]
Throughput
- High Throughput
Curated By
- BioGRID