BAIT
ITM2B
Bri, imBRI2
integral membrane protein 2B
GO Process (2)
GO Function (2)
GO Component (8)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
STX1A
syntaxin 1A (brain)
GO Process (10)
GO Function (15)
GO Component (15)
Gene Ontology Biological Process
- calcium ion-dependent exocytosis [ISO]
- intracellular protein transport [IBA]
- neurotransmitter transport [TAS]
- positive regulation of exocytosis [IDA]
- positive regulation of neurotransmitter secretion [IMP]
- regulation of exocytosis [IMP]
- response to gravity [IDA]
- secretion by cell [ISO]
- synaptic vesicle docking [IEP]
- synaptic vesicle fusion to presynaptic membrane [IBA]
Gene Ontology Molecular Function- ATP-dependent protein binding [IPI]
- SNAP receptor activity [IBA]
- SNARE binding [IDA, IPI, ISO]
- calcium channel inhibitor activity [ISO]
- calcium-dependent protein binding [IPI]
- chloride channel inhibitor activity [ISO]
- glycoprotein binding [IDA]
- kinase binding [ISO]
- myosin binding [IPI]
- myosin head/neck binding [IPI]
- protein N-terminus binding [IDA]
- protein binding [IPI]
- protein binding, bridging [IPI]
- protein domain specific binding [IPI]
- protein heterodimerization activity [IDA]
- ATP-dependent protein binding [IPI]
- SNAP receptor activity [IBA]
- SNARE binding [IDA, IPI, ISO]
- calcium channel inhibitor activity [ISO]
- calcium-dependent protein binding [IPI]
- chloride channel inhibitor activity [ISO]
- glycoprotein binding [IDA]
- kinase binding [ISO]
- myosin binding [IPI]
- myosin head/neck binding [IPI]
- protein N-terminus binding [IDA]
- protein binding [IPI]
- protein binding, bridging [IPI]
- protein domain specific binding [IPI]
- protein heterodimerization activity [IDA]
Gene Ontology Cellular Component
- SNARE complex [ISO, ISS]
- actomyosin [IDA]
- cell [ISO]
- integral component of membrane [NAS]
- intracellular organelle [IDA]
- membrane [ISO]
- neuron projection [ISO]
- plasma membrane [IDA, ISO]
- protein complex [IDA]
- secretory granule [IDA]
- synaptic vesicle [IBA, ISO]
- synaptic vesicle membrane [ISO]
- synaptobrevin 2-SNAP-25-syntaxin-1a complex [IDA, ISO]
- synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex [IDA]
- synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex [IDA]
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Identification and characterization of the BRI2 interactome in the brain.
BRI family proteins are ubiquitous type II transmembrane proteins but BRI2 is highly expressed in some neuronal tissues. Possible BRI2 functions include neuronal maturation and differentiation. Protein complexes appear to be important in mediating its functions. Previously described BRI2 interactors include the Alzheimer's amyloid precursor protein and protein phosphatase 1, but clearly the identification of novel interactors provides an important ... [more]
Sci Rep Feb. 23, 2018; 8(1);3548 [Pubmed: 29476059]
Throughput
- High Throughput
Curated By
- BioGRID