BAIT
ITM2B
Bri, imBRI2
integral membrane protein 2B
GO Process (2)
GO Function (2)
GO Component (8)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
THY1
CD7
Thy-1 cell surface antigen
GO Process (18)
GO Function (6)
GO Component (14)
Gene Ontology Biological Process
- T cell receptor signaling pathway [IMP]
- angiogenesis [ISO, ISS]
- cytoskeleton organization [IDA]
- focal adhesion assembly [IDA]
- mast cell activation [NAS]
- negative regulation of T cell receptor signaling pathway [ISO, ISS]
- negative regulation of apoptotic process [TAS]
- negative regulation of axonogenesis [IDA]
- negative regulation of cell migration [IDA]
- negative regulation of fibroblast proliferation [NAS]
- negative regulation of protein kinase activity [IDA]
- positive regulation of GTPase activity [IDA]
- positive regulation of Rho GTPase activity [IDA]
- positive regulation of T cell activation [IDA]
- positive regulation of peptidyl-tyrosine phosphorylation [NAS]
- positive regulation of release of sequestered calcium ion into cytosol [IDA]
- retinal cone cell development [ISO, ISS]
- single organismal cell-cell adhesion [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- anchored component of external side of plasma membrane [ISO]
- anchored component of plasma membrane [IDA]
- apical plasma membrane [ISO]
- cell surface [IDA, TAS]
- cytosol [IDA]
- dendrite [ISO]
- endoplasmic reticulum [ISO]
- external side of plasma membrane [ISO, ISS]
- extracellular vesicular exosome [ISO]
- focal adhesion [ISO]
- growth cone [IDA]
- membrane raft [ISO]
- myelin sheath [ISO]
- plasma membrane [IDA]
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Identification and characterization of the BRI2 interactome in the brain.
BRI family proteins are ubiquitous type II transmembrane proteins but BRI2 is highly expressed in some neuronal tissues. Possible BRI2 functions include neuronal maturation and differentiation. Protein complexes appear to be important in mediating its functions. Previously described BRI2 interactors include the Alzheimer's amyloid precursor protein and protein phosphatase 1, but clearly the identification of novel interactors provides an important ... [more]
Sci Rep Feb. 23, 2018; 8(1);3548 [Pubmed: 29476059]
Throughput
- High Throughput
Curated By
- BioGRID