BAIT
ITM2B
Bri, imBRI2
integral membrane protein 2B
GO Process (2)
GO Function (2)
GO Component (8)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
VAMP2
RATVAMPB, RATVAMPIR, SYB, Syb2
vesicle-associated membrane protein 2
GO Process (20)
GO Function (12)
GO Component (24)
Gene Ontology Biological Process
- Golgi to plasma membrane protein transport [ISO]
- calcium ion-dependent exocytosis [ISO]
- cellular response to insulin stimulus [ISO]
- eosinophil degranulation [ISO]
- long-term synaptic potentiation [ISO]
- membrane fusion [ISO]
- mucus secretion [ISO]
- natural killer cell degranulation [ISO]
- neurotransmitter secretion [IBA]
- neutrophil degranulation [ISO]
- positive regulation of intracellular protein transport [ISO]
- protein complex assembly [IDA]
- protein transport [IMP]
- regulation of exocytosis [IMP, ISO, TAS]
- regulation of histamine secretion by mast cell [ISO]
- regulation of vesicle-mediated transport [ISO]
- response to glucose [IDA]
- synaptic vesicle exocytosis [ISO]
- vesicle fusion [IBA]
- vesicle-mediated transport [IMP]
Gene Ontology Molecular Function- SNAP receptor activity [IBA]
- SNARE binding [IDA, ISO]
- calcium-dependent protein binding [IPI]
- calmodulin binding [ISO]
- identical protein binding [IPI]
- myosin binding [IPI]
- phospholipid binding [ISO]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- protein complex binding [IPI]
- syntaxin binding [ISO]
- syntaxin-1 binding [IDA, IPI]
- SNAP receptor activity [IBA]
- SNARE binding [IDA, ISO]
- calcium-dependent protein binding [IPI]
- calmodulin binding [ISO]
- identical protein binding [IPI]
- myosin binding [IPI]
- phospholipid binding [ISO]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- protein complex binding [IPI]
- syntaxin binding [ISO]
- syntaxin-1 binding [IDA, IPI]
Gene Ontology Cellular Component
- SNARE complex [IDA, ISO]
- cell [ISO]
- clathrin-coated vesicle [ISO, ISS]
- cytoplasmic vesicle [ISO]
- extracellular vesicular exosome [ISO]
- intracellular [ISO]
- intracellular membrane-bounded organelle [IDA]
- intracellular organelle [IDA]
- membrane [ISO, ISS]
- neuron projection [IDA]
- neuron projection terminus [IDA]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [IDA, ISO]
- secretory granule [IDA, ISO]
- secretory granule membrane [ISO]
- synapse [ISO]
- synaptic vesicle [IBA, IDA, ISO]
- synaptic vesicle membrane [ISO, NAS]
- synaptobrevin 2-SNAP-25-syntaxin-1a complex [IDA, ISO]
- synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex [IDA]
- synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex [IDA]
- terminal bouton [IDA]
- trans-Golgi network [ISO]
- zymogen granule membrane [ISO]
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Identification and characterization of the BRI2 interactome in the brain.
BRI family proteins are ubiquitous type II transmembrane proteins but BRI2 is highly expressed in some neuronal tissues. Possible BRI2 functions include neuronal maturation and differentiation. Protein complexes appear to be important in mediating its functions. Previously described BRI2 interactors include the Alzheimer's amyloid precursor protein and protein phosphatase 1, but clearly the identification of novel interactors provides an important ... [more]
Sci Rep Feb. 23, 2018; 8(1);3548 [Pubmed: 29476059]
Throughput
- High Throughput
Curated By
- BioGRID