BAIT
NDRG1
CAP43, CMT4D, DRG-1, DRG1, GC4, HMSNL, NDR1, NMSL, PROXY1, RIT42, RTP, TARG1, TDD5
N-myc downstream regulated 1
GO Process (4)
GO Function (5)
GO Component (10)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
APOA1
Alp-1, Apoa-1, Brp-14, Ltw-1, Lvtw-1, Sep-1, Sep-2, Sep2, apo-AI, apoA-I
apolipoprotein A-I
GO Process (53)
GO Function (19)
GO Component (14)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [ISO]
- adrenal gland development [IMP]
- axon regeneration [IGI]
- blood vessel endothelial cell migration [IMP]
- cholesterol biosynthetic process [IMP]
- cholesterol efflux [IDA, IMP, ISO]
- cholesterol homeostasis [IBA, ISO]
- cholesterol import [ISO]
- cholesterol metabolic process [IGI, IMP, ISO]
- cholesterol transport [IDA, IMP, ISO]
- endothelial cell proliferation [IMP]
- glucocorticoid metabolic process [IMP]
- high-density lipoprotein particle assembly [IBA, ISO]
- integrin-mediated signaling pathway [ISO]
- lipid storage [IMP]
- lipoprotein biosynthetic process [IGI, IMP]
- negative chemotaxis [ISO]
- negative regulation of cell adhesion molecule production [ISO]
- negative regulation of cytokine secretion involved in immune response [ISO]
- negative regulation of heterotypic cell-cell adhesion [ISO]
- negative regulation of hydrolase activity [IGI]
- negative regulation of inflammatory response [ISO]
- negative regulation of interleukin-1 beta secretion [ISO]
- negative regulation of lipase activity [ISO]
- negative regulation of response to cytokine stimulus [ISO]
- negative regulation of tumor necrosis factor-mediated signaling pathway [ISO]
- negative regulation of very-low-density lipoprotein particle remodeling [ISO]
- organ regeneration [ISO]
- peptidyl-methionine modification [ISO]
- phosphatidylcholine biosynthetic process [ISO]
- phosphatidylcholine metabolic process [IBA]
- phospholipid efflux [IBA, ISO]
- phospholipid homeostasis [ISO]
- phospholipid metabolic process [IMP]
- phospholipid transport [ISO]
- positive regulation of Rho protein signal transduction [ISO]
- positive regulation of cholesterol esterification [IBA, ISO]
- positive regulation of fatty acid biosynthetic process [IBA]
- positive regulation of hydrolase activity [ISO]
- positive regulation of lipoprotein lipase activity [IBA]
- positive regulation of stress fiber assembly [ISO]
- positive regulation of substrate adhesion-dependent cell spreading [ISO]
- positive regulation of transferase activity [IMP]
- positive regulation of triglyceride catabolic process [IBA]
- protein localization [IMP]
- protein oxidation [ISO]
- protein stabilization [ISO]
- regulation of Cdc42 protein signal transduction [ISO]
- regulation of intestinal cholesterol absorption [IDA]
- regulation of protein phosphorylation [IDA]
- reverse cholesterol transport [IBA, ISO]
- triglyceride homeostasis [IBA, ISO]
- very-low-density lipoprotein particle remodeling [IBA]
Gene Ontology Molecular Function- apolipoprotein A-I receptor binding [ISO]
- apolipoprotein receptor binding [ISO]
- beta-amyloid binding [ISO]
- chemorepellent activity [ISO]
- cholesterol binding [IBA, ISO]
- cholesterol transporter activity [IDA, ISO]
- enzyme binding [ISO]
- high-density lipoprotein particle binding [IDA]
- high-density lipoprotein particle receptor binding [IBA, ISO]
- identical protein binding [IPI, ISO]
- lipase inhibitor activity [ISO]
- lipid binding [IDA]
- lipid transporter activity [IDA, IMP]
- lipoprotein particle binding [IDA]
- phosphatidylcholine binding [IBA]
- phosphatidylcholine-sterol O-acyltransferase activator activity [IBA, ISO]
- phospholipid binding [ISO]
- phospholipid transporter activity [ISO]
- protein binding [IPI]
- apolipoprotein A-I receptor binding [ISO]
- apolipoprotein receptor binding [ISO]
- beta-amyloid binding [ISO]
- chemorepellent activity [ISO]
- cholesterol binding [IBA, ISO]
- cholesterol transporter activity [IDA, ISO]
- enzyme binding [ISO]
- high-density lipoprotein particle binding [IDA]
- high-density lipoprotein particle receptor binding [IBA, ISO]
- identical protein binding [IPI, ISO]
- lipase inhibitor activity [ISO]
- lipid binding [IDA]
- lipid transporter activity [IDA, IMP]
- lipoprotein particle binding [IDA]
- phosphatidylcholine binding [IBA]
- phosphatidylcholine-sterol O-acyltransferase activator activity [IBA, ISO]
- phospholipid binding [ISO]
- phospholipid transporter activity [ISO]
- protein binding [IPI]
Gene Ontology Cellular Component
- blood microparticle [IBA, ISO]
- cell surface [ISO]
- chylomicron [IBA]
- cytoplasmic vesicle [ISO]
- discoidal high-density lipoprotein particle [ISO]
- endocytic vesicle [ISO]
- extracellular region [IDA]
- extracellular space [IDA, ISO]
- extracellular vesicular exosome [ISO]
- high-density lipoprotein particle [IBA, ISO]
- nucleus [ISO]
- spherical high-density lipoprotein particle [ISO]
- very-low-density lipoprotein particle [ISO]
- vesicle [ISO]
Mus musculus
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
NDRG1 interacts with APO A-I and A-II and is a functional candidate for the HDL-C QTL on 8q24.
Hereditary Motor and Sensory Neuropathy Lom (HMSNL) is a severe autosomal recessive peripheral neuropathy, the most common form of demyelinating Charcot-Marie-Tooth (CMT) disease in the Roma (Gypsy) population. The mutated gene, N-myc downstream-regulated gene 1 (NDRG1), is widely expressed and has been implicated in a range of processes and pathways. To gain an insight into NDRG1 function we performed yeast ... [more]
Biochem. Biophys. Res. Commun. Jul. 15, 2005; 332(4);982-92 [Pubmed: 15922294]
Throughput
- Low Throughput
Curated By
- BioGRID