BAIT
NDRG1
CAP43, CMT4D, DRG-1, DRG1, GC4, HMSNL, NDR1, NMSL, PROXY1, RIT42, RTP, TARG1, TDD5
N-myc downstream regulated 1
GO Process (4)
GO Function (5)
GO Component (10)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
APOA2
Alp-2, ApoA-II, ApoAII, Apoa-2, Hdl-1
apolipoprotein A-II
GO Process (36)
GO Function (13)
GO Component (7)
Gene Ontology Biological Process
- beta-glucoside transport [NAS]
- cholesterol efflux [ISO]
- cholesterol homeostasis [IDA, IGI, IMP, ISO]
- cholesterol metabolic process [IGI, IMP]
- cholesterol transport [ISO]
- diacylglycerol catabolic process [ISO]
- fatty acid metabolic process [NAS]
- high-density lipoprotein particle assembly [ISO]
- high-density lipoprotein particle clearance [ISO]
- high-density lipoprotein particle remodeling [ISO]
- lipid transport [IMP]
- lipoprotein metabolic process [IDA]
- low-density lipoprotein particle remodeling [ISO]
- negative regulation of cholesterol import [ISO]
- negative regulation of cholesterol transport [ISO]
- negative regulation of cholesterol transporter activity [ISO]
- negative regulation of cytokine secretion involved in immune response [ISO]
- negative regulation of lipase activity [IMP, ISO]
- negative regulation of lipid catabolic process [ISO]
- negative regulation of very-low-density lipoprotein particle remodeling [ISO]
- organ regeneration [ISO]
- peptidyl-methionine modification [ISO]
- phosphatidylcholine biosynthetic process [ISO]
- phospholipid catabolic process [ISO]
- phospholipid efflux [ISO]
- positive regulation of catalytic activity [ISO]
- positive regulation of cholesterol esterification [ISO]
- positive regulation of interleukin-8 biosynthetic process [ISO]
- positive regulation of lipid catabolic process [ISO]
- protein folding [ISO]
- protein oxidation [ISO]
- regulation of intestinal cholesterol absorption [IMP]
- regulation of protein stability [ISO]
- response to glucose [ISO]
- reverse cholesterol transport [ISO]
- triglyceride-rich lipoprotein particle remodeling [ISO]
Gene Ontology Molecular Function- apolipoprotein receptor binding [ISO]
- cholesterol binding [ISO]
- cholesterol transporter activity [ISO]
- high-density lipoprotein particle binding [IMP]
- high-density lipoprotein particle receptor binding [ISO]
- lipase inhibitor activity [ISO]
- lipid binding [ISO]
- lipid transporter activity [ISO]
- phosphatidylcholine binding [ISO]
- phosphatidylcholine-sterol O-acyltransferase activator activity [ISO]
- phospholipid binding [ISO]
- protein heterodimerization activity [ISO]
- protein homodimerization activity [ISO]
- apolipoprotein receptor binding [ISO]
- cholesterol binding [ISO]
- cholesterol transporter activity [ISO]
- high-density lipoprotein particle binding [IMP]
- high-density lipoprotein particle receptor binding [ISO]
- lipase inhibitor activity [ISO]
- lipid binding [ISO]
- lipid transporter activity [ISO]
- phosphatidylcholine binding [ISO]
- phosphatidylcholine-sterol O-acyltransferase activator activity [ISO]
- phospholipid binding [ISO]
- protein heterodimerization activity [ISO]
- protein homodimerization activity [ISO]
Mus musculus
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
NDRG1 interacts with APO A-I and A-II and is a functional candidate for the HDL-C QTL on 8q24.
Hereditary Motor and Sensory Neuropathy Lom (HMSNL) is a severe autosomal recessive peripheral neuropathy, the most common form of demyelinating Charcot-Marie-Tooth (CMT) disease in the Roma (Gypsy) population. The mutated gene, N-myc downstream-regulated gene 1 (NDRG1), is widely expressed and has been implicated in a range of processes and pathways. To gain an insight into NDRG1 function we performed yeast ... [more]
Biochem. Biophys. Res. Commun. Jul. 15, 2005; 332(4);982-92 [Pubmed: 15922294]
Throughput
- Low Throughput
Curated By
- BioGRID