BAIT

TRIM59

2310035M22Rik, 2700022F13Rik, Mrf1, TSBF1
tripartite motif-containing 59
GO Process (4)
GO Function (2)
GO Component (1)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Mus musculus
PREY

ACTN1

3110023F10Rik, Actn1a
actinin, alpha 1
Mus musculus

Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

Embryonic lethality in mice lacking Trim59 due to impaired gastrulation development.

Su X, Wu C, Ye X, Zeng M, Zhang Z, Che Y, Zhang Y, Liu L, Lin Y, Yang R

TRIM family members have been implicated in a variety of biological processes such as differentiation and development. We here found that Trim59 plays a critical role in early embryo development from blastocyst stage to gastrula. There existed delayed development and empty yolk sacs from embryonic day (E) 8.5 in Trim59-/- embryos. No viable Trim59-/- embryos were observed beyond E9.5. Trim59 ... [more]

Cell Death Dis Feb. 21, 2018; 9(3);302 [Pubmed: 29467473]

Throughput

  • Low Throughput

Curated By

  • BioGRID