Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

Embryonic lethality in mice lacking Trim59 due to impaired gastrulation development.

Su X, Wu C, Ye X, Zeng M, Zhang Z, Che Y, Zhang Y, Liu L, Lin Y, Yang R

TRIM family members have been implicated in a variety of biological processes such as differentiation and development. We here found that Trim59 plays a critical role in early embryo development from blastocyst stage to gastrula. There existed delayed development and empty yolk sacs from embryonic day (E) 8.5 in Trim59-/- embryos. No viable Trim59-/- embryos were observed beyond E9.5. Trim59 ... [more]

Cell Death Dis Feb. 21, 2018; 9(3);302 [Pubmed: 29467473]

Throughput

Low Throughput

Curated By

BioGRID

Interaction Summary

TRIM59

Gene Ontology Biological Process

Gene Ontology Molecular Function

protein binding [IPI]ubiquitin protein ligase activity [IDA]

Gene Ontology Cellular Component

HOMER3

Gene Ontology Biological Process

Gene Ontology Molecular Function

G-protein coupled glutamate receptor binding [IBA]protein C-terminus binding [IPI]protein binding [IPI]protein domain specific binding [IPI]

Gene Ontology Cellular Component

Two-hybrid

Publication

Embryonic lethality in mice lacking Trim59 due to impaired gastrulation development.

Throughput

Curated By

protein binding [IPI]
ubiquitin protein ligase activity [IDA]

G-protein coupled glutamate receptor binding [IBA]
protein C-terminus binding [IPI]
protein binding [IPI]
protein domain specific binding [IPI]