UBXN2A
Gene Ontology Biological Process
- Golgi organization [IBA]
- autophagic vacuole assembly [IBA]
- membrane fusion [IBA]
- nuclear envelope reassembly [IBA]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IBA]
- regulation of catalytic activity [IBA]
- regulation of gene expression [ISO]
- regulation of protein catabolic process [IDA]
- regulation of protein ubiquitination [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
HSPA9
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
UBXN2A enhances CHIP-mediated proteasomal degradation of oncoprotein mortalin-2 in cancer cells.
Overexpression of oncoproteins is a major cause of treatment failure using current chemotherapeutic drugs. Drug-induced degradation of oncoproteins is feasible and can improve clinical outcomes in diverse types of cancers. Mortalin-2 (mot-2) is a dominant oncoprotein in several tumors, including colorectal cancer (CRC). In addition to inactivating the p53 tumor suppressor protein, mot-2 enhances tumor cell invasion and migration. Thus, ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID