PPP1CC
Gene Ontology Biological Process
- circadian regulation of gene expression [ISS]
- entrainment of circadian clock by photoperiod [ISS]
- mitotic cell cycle [TAS]
- negative regulation of transforming growth factor beta receptor signaling pathway [TAS]
- protein dephosphorylation [IMP, ISS]
- regulation of circadian rhythm [IMP]
- small molecule metabolic process [TAS]
- transforming growth factor beta receptor signaling pathway [TAS]
- triglyceride catabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CHRNA7
Gene Ontology Biological Process
- activation of MAPK activity [IDA]
- calcium ion transport [IDA, IMP]
- cation transmembrane transport [IDA]
- cellular calcium ion homeostasis [IMP]
- cognition [IMP, NAS]
- ion transmembrane transport [IDA]
- ion transport [NAS]
- memory [NAS]
- negative regulation of tumor necrosis factor production [IDA, IMP]
- positive regulation of angiogenesis [IMP]
- positive regulation of cell proliferation [IMP]
- response to hypoxia [IDA]
- response to nicotine [IDA]
- signal transduction [IDA]
- synaptic transmission [TAS]
Gene Ontology Molecular Function- acetylcholine binding [IDA]
- acetylcholine receptor activity [IDA]
- acetylcholine-activated cation-selective channel activity [IDA]
- acetylcholine-gated cation channel activity [IDA]
- beta-amyloid binding [IPI]
- chloride channel regulator activity [IDA]
- protein homodimerization activity [IDA]
- toxic substance binding [IDA]
- acetylcholine binding [IDA]
- acetylcholine receptor activity [IDA]
- acetylcholine-activated cation-selective channel activity [IDA]
- acetylcholine-gated cation channel activity [IDA]
- beta-amyloid binding [IPI]
- chloride channel regulator activity [IDA]
- protein homodimerization activity [IDA]
- toxic substance binding [IDA]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
α7nAChR-mediated recruitment of PP1γ promotes TRAF6/NF-κB cascade to facilitate the progression of Hepatocellular Carcinoma.
The cholinergic signaling pathways have been recently implicated in the development of various human cancers. However, the underlying molecular mechanism remains largely unclear. In the present study, we reported that α7 nicotinic acetylcholine receptor (α7nAChR), an important member of nicotinic acetylcholine receptors, interacts with Protein Phosphatase-1γ (PP1γ) in human Hepatocellular Carcinoma (HCC) tissues. In addition, we found that α7nAChR facilitates ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CHRNA7 PPP1CC | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| PPP1CC CHRNA7 | Co-localization Co-localization Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments. | Low | - | BioGRID | - |
Curated By
- BioGRID