BAG5
Gene Ontology Biological Process
- negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [ISO]
- negative regulation of proteasomal ubiquitin-dependent protein catabolic process [ISO]
- negative regulation of protein refolding [ISO, ISS]
- negative regulation of protein ubiquitination [ISO, ISS]
- negative regulation of ubiquitin-protein transferase activity [ISO, ISS]
- neuron death [ISO, ISS]
- regulation of inclusion body assembly [ISO, ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
GAK
Gene Ontology Biological Process
- Golgi organization [IMP]
- cell development [IMP]
- clathrin coat disassembly [IGI]
- clathrin-mediated endocytosis [IMP]
- endoplasmic reticulum organization [IMP]
- epidermal cell differentiation [IMP]
- establishment of skin barrier [IMP]
- forebrain morphogenesis [IMP]
- intrahepatic bile duct development [IMP]
- positive regulation of neural precursor cell proliferation [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease.
Mutations in leucine-rich repeat kinase 2 (LRRK2) cause inherited Parkinson disease (PD), and common variants around LRRK2 are a risk factor for sporadic PD. Using protein-protein interaction arrays, we identified BCL2-associated athanogene 5, Rab7L1 (RAB7, member RAS oncogene family-like 1), and Cyclin-G-associated kinase as binding partners of LRRK2. The latter two genes are candidate genes for risk for sporadic PD ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID