USP8
Gene Ontology Biological Process
- cell proliferation [TAS]
- endosome organization [IMP]
- mitotic cytokinesis [IMP]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IBA]
- protein K48-linked deubiquitination [IDA]
- protein K63-linked deubiquitination [IDA]
- protein deubiquitination [IMP]
- regulation of proteasomal protein catabolic process [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PPP2R4
Gene Ontology Biological Process
- ATP catabolic process [IDA]
- mitotic spindle organization in nucleus [IBA]
- negative regulation of phosphoprotein phosphatase activity [IDA]
- negative regulation of protein dephosphorylation [IDA]
- positive regulation of apoptotic process [IDA]
- positive regulation of phosphoprotein phosphatase activity [IDA]
- positive regulation of protein dephosphorylation [IDA]
- protein peptidyl-prolyl isomerization [IBA]
- regulation of phosphoprotein phosphatase activity [IDA]
Gene Ontology Molecular Function- ATP binding [IDA]
- ATPase activity [IDA]
- peptidyl-prolyl cis-trans isomerase activity [IBA]
- protein heterodimerization activity [TAS]
- protein homodimerization activity [IDA]
- protein phosphatase 2A binding [IDA]
- protein phosphatase type 2A regulator activity [IDA, TAS]
- protein tyrosine phosphatase activator activity [IDA]
- receptor binding [IPI]
- ATP binding [IDA]
- ATPase activity [IDA]
- peptidyl-prolyl cis-trans isomerase activity [IBA]
- protein heterodimerization activity [TAS]
- protein homodimerization activity [IDA]
- protein phosphatase 2A binding [IDA]
- protein phosphatase type 2A regulator activity [IDA, TAS]
- protein tyrosine phosphatase activator activity [IDA]
- receptor binding [IPI]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Stratifin regulates stabilization of receptor tyrosine kinases via interaction with ubiquitin-specific protease 8 in lung adenocarcinoma.
Previously we have reported that stratifin (SFN, 14-3-3 sigma) acts as a novel oncogene, accelerating the tumor initiation and progression of lung adenocarcinoma. Here, pull-down assay and LC-MS/MS analysis revealed that ubiquitin-specific protease 8 (USP8) specifically bound to SFN in lung adenocarcinoma cells. Both USP8 and SFN showed higher expression in human lung adenocarcinoma than in normal lung tissue, and ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID