BAIT
UBC
2700054O04Rik, AI194771, Rps27a, TI-225, Uba52, Ubb
ubiquitin C
GO Process (1)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
ATP5A1
AI035633, AL022851, AL023067, Atpm, D18Ertd206e, Mom2
ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1
GO Process (7)
GO Function (6)
GO Component (10)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- COP9 signalosome [ISO]
- extracellular vesicular exosome [ISO]
- membrane [ISO]
- mitochondrial inner membrane [IDA, ISO]
- mitochondrial proton-transporting ATP synthase complex [ISO]
- mitochondrial proton-transporting ATP synthase complex, catalytic core F(1) [ISO]
- mitochondrion [IDA, ISO]
- myelin sheath [IDA]
- plasma membrane [ISO]
- proton-transporting ATP synthase complex, catalytic core F(1) [ISO]
Mus musculus
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Mfn2 ubiquitination by PINK1/parkin gates the p97-dependent release of ER from mitochondria to drive mitophagy.
Despite their importance as signaling hubs, the function of mitochondria-ER contact sites in mitochondrial quality control pathways remains unexplored. Here we describe a mechanism by which Mfn2, a mitochondria-ER tether, gates the autophagic turnover of mitochondria by PINK1 and parkin. Mitochondria-ER appositions are destroyed during mitophagy, and reducing mitochondria-ER contacts increases the rate of mitochondrial degradation. Mechanistically, parkin/PINK1 catalyze a ... [more]
Elife Apr. 20, 2018; 7(); [Pubmed: 29676259]
Throughput
- Low Throughput
Additional Notes
- #LPPI
- likely protein-protein interaction
Curated By
- BioGRID