BAIT
UBC
2700054O04Rik, AI194771, Rps27a, TI-225, Uba52, Ubb
ubiquitin C
GO Process (1)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
DNAJB6
Mrj, mDj4
DnaJ (Hsp40) homolog, subfamily B, member 6
GO Process (13)
GO Function (7)
GO Component (7)
Gene Ontology Biological Process
- actin cytoskeleton organization [IMP]
- chaperone-mediated protein folding [ISO]
- chorio-allantoic fusion [IMP]
- chorion development [IMP]
- extracellular matrix organization [IMP]
- intermediate filament organization [ISO]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- negative regulation of inclusion body assembly [ISO]
- negative regulation of transcription, DNA-templated [IDA]
- positive regulation of ATPase activity [ISO]
- protein folding [ISO]
- protein localization to nucleus [IMP]
- syncytiotrophoblast cell differentiation involved in labyrinthine layer development [IMP]
Gene Ontology Molecular Function
Mus musculus
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Mfn2 ubiquitination by PINK1/parkin gates the p97-dependent release of ER from mitochondria to drive mitophagy.
Despite their importance as signaling hubs, the function of mitochondria-ER contact sites in mitochondrial quality control pathways remains unexplored. Here we describe a mechanism by which Mfn2, a mitochondria-ER tether, gates the autophagic turnover of mitochondria by PINK1 and parkin. Mitochondria-ER appositions are destroyed during mitophagy, and reducing mitochondria-ER contacts increases the rate of mitochondrial degradation. Mechanistically, parkin/PINK1 catalyze a ... [more]
Elife Apr. 20, 2018; 7(); [Pubmed: 29676259]
Throughput
- Low Throughput
Additional Notes
- #LPPI
- likely protein-protein interaction
Curated By
- BioGRID